Real-World Strategies to Treat Hypertension Associated with Pediatric Obesity.
Real-World Strategies to Treat Hypertension Associated with Pediatric Obesity.
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DOI：
10.1007/s11906-019-0922-2
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发表时间：
2019-02-12
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
回顾当前治疗儿童肥胖相关高血压策略的最新文献。在过去的三十年里，美国的儿童和青少年超重和肥胖患病率持续上升。不出所料，但相当令人不安的是，这种上升的患病率与儿童时期心血管疾病（CVD）危险因素（如高血压、血脂异常和糖尿病）的增加相平行，这些风险因素比以前报道的更早出现。这些儿童CVD危险因素不仅与儿童时期的靶器官损伤有关，而且还会追踪到成年期，增加长期CVD发病率和死亡率的风险。已经提出了几种机制来解释肥胖在儿童期高血压发展中的作用。然而，肥胖相关高血压的核心管理是一个以生活方式改变和体重减轻为目标的多方面的方法。有效的治疗通常还需要药物治疗，很少需要减肥手术。
To review the most recent literature on current strategies for the treatment of hypertension associated with pediatric obesity. Over the last three decades, childhood and adolescent overweight and obesity prevalence in the USA has continued to rise. Unsurprisingly but rather disturbingly, this rising prevalence has been paralleled by an increase in cardiovascular disease (CVD) risk factors in childhood such as hypertension, dyslipidemia, and diabetes that become manifest earlier than previously reported. These childhood CVD risk factors are not only associated with target organ damage in childhood but also track into adulthood, increasing the risk of long-term CVD morbidity and mortality. There have been several mechanisms proposed to explain the role of obesity on the development of hypertension in childhood. However, central to the management of obesity-related hypertension is a multifaceted approach targeting lifestyle modifications and weight loss. Effective treatment often also requires a pharmacologic approach and rarely bariatric surgery.
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影响因子：
8
作者：
Barlow, Sarah E.
通讯作者：
Barlow, Sarah E.
影响因子：
3.1
作者：
Inge, Thomas H.;Coley, R. Yates;Michalsky, Marc
通讯作者：
Michalsky, Marc
影响因子：
2.6
作者：
Brady TM
通讯作者：
Brady TM
影响因子：
120.7
作者：
Grossman, David C.;Bibbins-Domingo, Kirsten;Tseng, Chien-Wen
通讯作者：
Tseng, Chien-Wen
DOI：
10.1016/j.jash.2008.05.005
发表时间：
2008-11-01
影响因子：
--
作者：
Calhoun, David A.;White, William B.
通讯作者：
White, William B.