Retinal vessel tortuosity associated with central retinal vein occlusion: an optical coherence tomography study.
Retinal vessel tortuosity associated with central retinal vein occlusion: an optical coherence tomography study.
复制标题
DOI：
10.1167/iovs.13-13201
复制
发表时间：
2014
影响因子：
4.4
通讯作者：
Yuki Muraoka;A. Tsujikawa;K. Kumagai;Yumiko Akagi-Kurashige;K. Ogino;T. Murakami;K. Miyamoto;N. Yoshimura
中科院分区：
文献类型：
--
作者：
Yuki Muraoka;A. Tsujikawa;K. Kumagai;Yumiko Akagi-Kurashige;K. Ogino;T. Murakami;K. Miyamoto;N. Yoshimura
目的应用光学相干断层扫描（OCT）技术研究视网膜中央静脉阻塞（CRVO）患者视网膜血管的形态学改变。方法对35例35眼急性CRVO患者的视网膜主要血管进行前瞻性纵向薄层切片和视乳头周围扫描。在随机选择的主要颞静脉的纵向OCT图像上量化与CRVO相关的前后静脉迂曲。在给定静脉的OCT切片上，我们确定了血管壁的最内点和最外点。前后静脉迂曲程度定义为视网膜色素上皮与静脉腔中心在这两个点的垂直距离之差。结果OCT图像显示，视网膜大静脉在肿胀的感觉神经层内从视网膜内表面曲折走行至视网膜色素上皮。前后静脉迂曲程度与视力差（r = 0.457，P = 0.017）、平均中心凹厚度增加（r = 0.671，P < 0.001）和中心凹脱离高度（r = 0.414，P = 0.032）相关。在4只（11%）眼中，在视盘周围检测到局部视网膜脱离，这与前后静脉迂曲相关。在14只（40%）眼中，视网膜大静脉延长破坏了视网膜血管和实质之间的边界，导致神经感觉视网膜的近静脉分裂。结论：在患有CRVO的眼睛中，OCT可用于显示前后静脉迂曲和视网膜实质的相关结构变化。
PURPOSE We studied morphologic changes of the retinal vasculature in eyes with central retinal vein occlusion (CRVO) through the use of optical coherence tomography (OCT). METHODS Major retinal vessels in 35 eyes from 35 consecutive patients with acute CRVO were examined prospectively and longitudinally with sequential thin sectioning and circumpapillary scanning. Anteroposterior venous tortuosity associated with CRVO was quantified on longitudinal OCT images of a randomly selected major temporal vein. On OCT sections of a given vein, we identified the innermost and outermost points of the vessel wall. The degree of anteroposterior venous tortuosity was defined as the difference between the vertical distances from the retinal pigment epithelium to the center of the venous lumen at these two points. RESULTS The OCT images revealed that the major retinal veins traveled tortuously through the swollen neurosensory retina from the inner retinal surface to the retinal pigment epithelium. The degree of anteroposterior venous tortuosity was correlated with poor visual acuity (r = 0.457, P = 0.017), increased mean foveal thickness (r = 0.671, P < 0.001), and the height of foveal detachment (r = 0.414, P = 0.032). In 4 (11%) eyes, a localized retinal detachment was detected around the optic disc, which correlated with anteroposterior venous tortuosity. In 14 (40%) eyes, elongated major retinal veins disrupted the boundary between retinal vessels and parenchyma, which resulted in juxtavenous splitting of the neurosensory retina. CONCLUSIONS In eyes with CRVO, OCT can be used to visualize anteroposterior venous tortuosity and associated structural changes to the retinal parenchyma.