Role of tumor microenvironment in tumorigenesis.
Role of tumor microenvironment in tumorigenesis.
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肿瘤微环境在肿瘤发生中的作用
DOI：
10.7150/jca.17648
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发表时间：
2017
影响因子：
3.9
通讯作者：
Guo C
中科院分区：
文献类型：
--
作者：
Wang M;Zhao J;Zhang L;Wei F;Lian Y;Wu Y;Gong Z;Zhang S;Zhou J;Cao K;Li X;Xiong W;Li G;Zeng Z;Guo C
肿瘤发生是一个复杂的动态过程，包括三个阶段：起始、进展和转移。肿瘤被细胞外基质（ECM）和基质细胞包围，肿瘤微环境（TME）的生理状态与肿瘤发生的每一步密切相关。有证据表明，TME的重要组成部分是成纤维细胞和肌成纤维细胞、神经内分泌细胞、脂肪细胞、免疫和炎症细胞、血液和淋巴管网络以及ECM。本文基于目前对TME的研究，对TME各组分在癌症发生、进展和侵袭中的主要功能进行了更全面的概述。该手稿还包括每个球员的主要治疗靶向标记物，这可能有助于治疗肿瘤。
Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation, progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and stromal cells, and the physiological state of the tumor microenvironment (TME) is closely connected to every step of tumorigenesis. Evidence suggests that the vital components of the TME are fibroblasts and myofibroblasts, neuroendocrine cells, adipose cells, immune and inflammatory cells, the blood and lymphatic vascular networks, and ECM. This manuscript, based on the current studies of the TME, offers a more comprehensive overview of the primary functions of each component of the TME in cancer initiation, progression, and invasion. The manuscript also includes primary therapeutic targeting markers for each player, which may be helpful in treating tumors.