The role of body weight in the relationship between physical activity and endometrial cancer: Results from a large cohort of US women
The role of body weight in the relationship between physical activity and endometrial cancer: Results from a large cohort of US women
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DOI：
10.1002/ijc.23716
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发表时间：
2008-10-15
影响因子：
6.4
通讯作者：
Calle, Eugenia E.
中科院分区：
文献类型：
--
作者：
Patel, Alpa V.;Feigelson, Heather Spencer;Calle, Eugenia E.
影响循环雌激素水平的因素、胰岛素介导的途径或通过肥胖相关机制实现的能量平衡，如体力活动，已被认为是子宫内膜癌的潜在危险因素。我们使用1992年基线获得的信息，在美国癌症协会癌症预防研究11营养队列中检查了体力活动与子宫内膜癌风险之间的关系，这是一项关于癌症发病率和死亡率的前瞻性研究。从1992年到2003年，在登记时未患癌症的42,672名子宫完整的绝经后妇女中，发现了466例子宫内膜癌。使用COX比例风险模型计算危险比(RR)，同时调整潜在混杂因素。为了评估体重指数(BMI)在这种关系中的作用，我们计算了多变量RR，在调整和不调整BMI的情况下，并根据BMI进行分层。所有体力活动和避免久坐行为的测量都与较低的子宫内膜癌风险相关。基线娱乐性体力活动与33%的风险降低相关(RR=0.67，31.5+与
Factors influencing circulating estrogen levels, insulin-mediated pathways or energy balance through obesity-related mechanisms, such as physical activity, have been proposed as potential risk factors for endometrial cancer. We examined measures of physical activity in relation to endometrial cancer risk in the American Cancer Society Cancer Prevention Study 11 Nutrition Cohort, a prospective study of cancer incidence and mortality, using information obtained at baseline in 1992. From 1992 to 2003, 466 incident endometrial cancers were identified among 42,672 postmenopausal women with intact uteri who were cancer-free at enrollment. Cox proportional hazards modeling was used to compute hazard rate ratios (RR) while adjusting for potential confounders. To assess the role of body mass index (BMI) in this relationship, we computed multivariate RR with and without adjustment for BMI and stratifying by BMI. All measures of physical activity and the avoidance of sedentary behavior were associated with lower endometrial cancer risk. Baseline recreational physical activity was associated with 33 % lower risk (RR = 0.67, 95% CI 0.44-1.03 for 31.5+ vs.