Controlling the Encapsulation of Charged Molecules in Vesicle-Templated Nanocontainers through Electrostatic Interactions with the Bilayer Scaffold
Controlling the Encapsulation of Charged Molecules in Vesicle-Templated Nanocontainers through Electrostatic Interactions with the Bilayer Scaffold
复制标题
通过与双层支架的静电相互作用控制囊泡模板纳米容器中带电分子的封装
DOI：
10.1021/acs.langmuir.7b01706
复制
发表时间：
2017
期刊：
影响因子：
3.9
通讯作者：
Pinkhassik, Eugene
中科院分区：
文献类型：
--
作者：
Kim, Mariya D.;Dergunov, Sergey A.;Pinkhassik, Eugene
这项工作解决了创建具有受控数量的封装分子的中空纳米胶囊的挑战。这种纳米容器或类似纳米拨浪鼓的结构代表了构建功能器件（包括纳米反应器和纳米传感器）的有吸引力的平台。通过利用带相反电荷的货物分子与通过混合单尾阳离子和阴离子表面活性剂形成的阴阳离子囊泡模板双层表面之间的静电吸引力，我们能够实现囊泡模板纳米胶囊内分子局部浓度的大幅增加。通过改变阴阳离子囊泡的配方或溶液的 pH 值来控制静电相互作用，从而能够微调捕获离子溶质的封装效率。控制捕获分子数量的能力极大地扩展了纳米容器在创建功能性纳米器件中的应用。
This work addresses the challenge of creating hollow nanocapsules with a controlled quantity of encapsulated molecules. Such nanocontainers or nanorattle-like structures represent an attractive platform for building functional devices, including nanoreactors and nanosensors. By taking advantage of the electrostatic attraction between oppositely charged cargo molecules and the surface of the templating bilayer of catanionic vesicles, formed by mixing single-tailed cationic and anionic surfactants, we were able to achieve a substantial increase in the local concentration of molecules inside the vesicle-templated nanocapsules. Control of electrostatic interactions through changes in the formulation of catanionic vesicles or the pH of the solution enabled fine tuning of the encapsulation efficiency in capturing ionic solutes. The ability to control the quantity of entrapped molecules greatly expands the application of nanocontainers in the creation of functional nanodevices.