CagA-positive Helicobacter pylori infection is not associated with decreased risk of Barrett's esophagus in a population with high H. pylori infection rate.
CagA-positive Helicobacter pylori infection is not associated with decreased risk of Barrett's esophagus in a population with high H. pylori infection rate.
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DOI：
10.1186/1471-230x-6-7
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发表时间：
2006-02-16
影响因子：
2.4
通讯作者：
Lanas A
中科院分区：
文献类型：
--
作者：
Ferrández A;Benito R;Arenas J;García-González MA;Sopeña F;Alcedo J;Ortego J;Sainz R;Lanas A
H.幽门螺杆菌感染在Barrett食管的发生发展中起着重要作用，Barrett食管（BE）的发病机制尚不明确。我们检验了cagA+幽门螺杆菌菌株感染可预防BE发生的假设。我们研究了104名连续患者，他们居住在H.幽门螺杆菌感染，BE和213名性别和年龄匹配的对照。H. pylori感染和CagA抗体状态通过蛋白质印迹血清学测定。H.幽门螺杆菌患病率在BE患者中高于对照组（87.5% vs. 74.6%; OR. 2.3; 95% CI：1.23-4.59）。年龄的增长与H. pylori（p < 0.05）。CagA+ H.幽门螺杆菌血清学在BE患者和对照组中相似（64.4% vs. 54.5%; NS）。I型H。幽门螺杆菌感染（CagA+和VacA+）在BE患者和对照组中相似（44.2%对41.3%; NS）。Logistic回归分析确定了酒精（O.R. 7.09; 95%CI 2.23-22.51）和H. pylori感染（OR：2.41，95%CI：1.20-4.84）而非CagA+血清学作为独立因素。也不是H。pylori感染和H. CagA+菌株的pylori感染降低了高H患病率人群中BE的风险。幽门感染
The role that H. pylori infection plays in the development of and Barrett's esophagus (BE) is uncertain. We tested the hypothesis that infection with cagA+ Helicobacter pylori strains protects against the development of BE. We studied 104 consecutive patients, residents in an area with a high prevalence of H. pylori infection, with BE and 213 sex- and age-matched controls. H. pylori infection and CagA antibody status were determined by western blot serology. H. pylori prevalence was higher in patients with BE than in controls (87.5% vs. 74.6%; OR. 2.3; 95% CI: 1.23–4.59). Increasing age was associated with a higher prevalence of H. pylori (p < 0.05). The prevalence of CagA+ H. pylori serology was similar in patients with BE and controls (64.4% vs. 54.5%; NS). Type I H. pylori infection (CagA+ and VacA+) was similar in patients with BE and controls (44.2% vs. 41.3%; NS). Logistic regression analysis identified alcohol (O.R. 7.09; 95% CI 2.23–22.51), and H. pylori infection (OR: 2.41; 95%CI: 1.20–4.84) but not CagA+ serology as independent factors. Neither H. pylori infection nor H. pylori infection by CagA+ strains reduce the risk of BE in a population with high prevalence of H. pylori infection.