Saccadic eye movements in families multiply affected with schizophrenia: The Maudsley family study
Saccadic eye movements in families multiply affected with schizophrenia: The Maudsley family study
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DOI：
10.1176/ajp.155.12.1703
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发表时间：
1998-12-01
影响因子：
17.7
通讯作者：
Lewis, SW
中科院分区：
文献类型：
--
作者：
Crawford, TJ;Sharma, T;Lewis, SW
目的：家族性研究表明，精神分裂症先证者的成年亲属以及先证者本身的顺畅追踪眼动异常增多。最近，精神分裂症受试者无法可靠地抑制反射性眼跳。这项研究旨在验证后一种功能障碍是扩展精神分裂症表型的一部分这一假设。方法：采用红外眼科成像技术，对29例精神分裂症先证者、50例非精神病一级亲属和38例健康志愿者进行了反射性眼跳和反眼跳的测量。结果：先证者、亲属和健康受试者在反射性眼跳的产生方面没有总体差异。然而，在反眼跳任务中，当被要求抑制反射性眼跳时，先证者表现出更多的眼跳分心。对矫正眼跳的分析表明，这不是由于理解或动机失败造成的。眼跳注意力高度分散的先证者的亲属比注意力正常的先证者的亲属表现出更高的分心率。在所有受试者中，女性表现出比男性更高的注意力错误率。结论：抑制反射性眼跳的能力是一种客观的神经认知测量，在精神分裂症患者及其部分亲缘中是受损的。这种反眼跳异常可能是精神分裂症患者及其家人的一个易损性标记。
Objective: Family studies have shown that abnormalities of smooth pursuit eye movement are increased in the adult relatives of schizophrenic probands as well as in the probands themselves. More recently, an inability of schizophrenic subjects to inhibit reflexive saccades reliably has been shown. This study aimed to test the hypothesis that the latter dysfunction is part of the extended schizophrenia phenotype. Method: With the use of infrared oculography, measurements of reflexive saccades and antisaccades were undertaken in 29 probands with schizophrenia, 50 of their nonpsychotic first-degree relatives, and 38 unrelated healthy volunteers. Results: Probands, relatives, and healthy subjects showed no overall differences in the generation of reflexive saccades. However, in the antisaccade task, probands showed more saccadic distractibility when they were required to inhibit reflexive saccades. Analysis of corrective saccades showed that this was not due to failed comprehension or motivation. Relatives of the probands with high saccadic distractibility showed a higher distractibility rate than relatives of the probands with normal distractibility. Across all subjects, females showed a higher rate of distractibility errors than males. Conclusions: The ability to suppress reflexive saccades is an objective neurocognitive measure that is impaired in schizophrenic patients and in a proportion of their biological relatives. This antisaccade abnormality may be a vulnerability marker in a subset of schizophrenic patients and their families.