A multiethnic cohort in Hawaii and Los Angeles: Baseline characteristics
A multiethnic cohort in Hawaii and Los Angeles: Baseline characteristics
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DOI：
10.1093/oxfordjournals.aje.a010213
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发表时间：
2000-02-15
影响因子：
5
通讯作者：
Nagamine, FS
中科院分区：
文献类型：
--
作者：
Kolonel, LN;Henderson, BE;Nagamine, FS
作者描述了在美国建立的研究饮食和癌症的大型多种族队列的设计和实施。他们详细说明了研究对象的来源、样本量、调查问卷的编制、试点工作。以及未来分析的方法。该队列包括215,251名成年男性和女性（基线年龄为45-75岁），生活在夏威夷和加利福尼亚（主要是洛杉矶县），种族分布如下：非裔美国人（16.3%），拉丁裔（22.0%），日裔美国人（26.4%），夏威夷原住民（6.5%），白人（22.9%）和其他血统（5.8%）。从1993年到1996年，参与者通过完成一份26页的自我管理的邮件问卷进入队列，该问卷获得了定量的食物频率历史，以及人口统计和其他信息。回应率从拉丁裔的20%到日裔美国人的49%不等。正如预期的那样，在种族群体内部和种族群体之间，问卷数据显示饮食摄入量（营养素和食物）和非饮食风险因素（包括吸烟、饮酒、肥胖和体育活动）的分布存在很大差异。当与相应的种族特异性癌症发病率进行比较时，研究结果为当前的几种饮食假设提供了初步支持。由于通过对队列的监测确定了足够数量的癌症病例，因此将在前瞻性分析中检验饮食和其他假设。
The authors describe the design and implementation of a large multiethnic cohort established to study diet and cancer in the United States. They detail the source of the subjects, sample size, questionnaire development, pilot work. and approaches to future analyses. The cohort consists of 215,251 adult men and women (age 45-75 years at baseline) living in Hawaii and in California (primarily Los Angeles County) with the following ethnic distribution: African-American (16.3%), Latino (22.0%), Japanese-American (26.4%), Native Hawaiian (6.5%), White (22.9%), and other ancestry (5.8%). From 1993 to 1996, participants entered the cohort by completing a 26-page, self-administered mail questionnaire that elicited a quantitative food frequency history, along with demographic and other information. Response rates ranged from 20% in Latinos to 49% in Japanese-Americans. As expected, both within and among ethnic groups, the questionnaire data show substantial variations in dietary intakes (nutrients as well as foods) and in the distributions of non-dietary risk factors (including smoking, alcohol consumption, obesity, and physical activity). When compared with corresponding ethnic-specific cancer incidence rates, the findings provide tentative support for several current dietary hypotheses. As sufficient numbers of cancer cases are identified through surveillance of the cohort, dietary and other hypotheses will be tested in prospective analyses.