A description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis.
A description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis.
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DOI：
10.3389/fendo.2023.1127550
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
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作者：
肺结核是一种炎症性疾病，与感染部位皮质醇/可的松比值升高和一系列细胞因子变化相关。结核性心包炎是一种不太常见但更致命的结核病，在心包中有类似的炎症过程。由于心包在很大程度上是不可接近的，结核性心包炎对心包糖皮质激素的影响在很大程度上是未知的。我们希望描述心包皮质醇/可的松比值与血浆和唾液皮质醇/可的松比值以及相关细胞因子浓度变化的关系。中位数血浆、心包和唾液皮质醇浓度（四分位距）分别为443（379-532）、303（257-384）和20（10-32）nmol/L，血浆、心包和唾液可的松浓度的四分位数范围分别为49（35-57）、15.0（0.0-21.7）和37（25-55）nmol/L。皮质醇/可的松比率在心包中最高，中位数（四分位数间距）为20（13-445），其次是血浆9.1（7.4-12.1）和唾液0.4（0.3-0.8）。皮质醇/可的松比值升高与心包、干扰素γ、肿瘤坏死因子-α、白细胞介素-6、白细胞介素-8和诱导蛋白10升高相关。单次给予120 mg泼尼松龙与给药后24小时内心包皮质醇和可的松的抑制有关。皮质醇/可的松比率在感染部位最高，在这种情况下，心包。升高的比率与不同的细胞因子应答相关。观察到的心包皮质醇抑制表明，120 mg泼尼松龙足以引起心包的免疫调节作用。
Pulmonary tuberculosis is an inflammatory disease associated with an elevated cortisol/cortisone ratio at the site of infection and an array of cytokine changes. Tuberculous pericarditis is a less common but more lethal form of tuberculosis and has a similar inflammatory process in the pericardium. As the pericardium is largely inaccessible, the effect of tuberculous pericarditis on pericardial glucocorticoids is largely unknown. We wished to describe pericardial cortisolcortisone ratio in relation to plasma and saliva cortisol/cortisone ratios and the associated changes in cytokine concentrations. The median (interquartile range) of plasma, pericardial, and saliva cortisol concentration was 443 (379–532), 303 (257–384), and 20 (10–32) nmol/L, respectively, whereas the median (interquartile range) of plasma, pericardial, and saliva cortisone concentrations was 49 (35–57), 15.0 (0.0–21.7), and 37 (25–55) nmol/L, respectively. The cortisol/cortisone ratio was highest in pericardium with median (interquartile range) of 20 (13–445), followed by plasma of 9.1 (7.4–12.1) and saliva of 0.4 (0.3–0.8). The elevated cortisol/cortisone ratio was associated with elevated pericardial, interferon gamma, tumor necrosis factor–alpha, interleukin-6, interleukin-8, and induced protein 10. Administration of a single dose of 120 mg of prednisolone was associated with the suppression of pericardial cortisol and cortisone within 24 h of administration. The cortisol/cortisone ratio was highest at the site of infection, in this case, the pericardium. The elevated ratio was associated with a differential cytokine response. The observed pericardial cortisol suppression suggests that 120 mg of prednisolone was sufficient to evoke an immunomodulatory effect in the pericardium.
DOI：
10.1016/j.ijcha.2017.10.002
发表时间：
2018-03
期刊：
International journal of cardiology. Heart & vasculature
影响因子：
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作者：
Shenje J;Lai RP;Ross IL;Mayosi BM;Wilkinson RJ;Ntsekhe M;Wilkinson KA
通讯作者：
Wilkinson KA