Area identity shifts in the early cerebral cortex of Emx2-/- mutant mice
Area identity shifts in the early cerebral cortex of Emx2-/- mutant mice
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DOI：
10.1038/76630
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发表时间：
2000-07-01
影响因子：
25
通讯作者：
Boncinelli, E
中科院分区：
文献类型：
--
作者：
Mallamaci, A;Muzio, L;Boncinelli, E
大脑皮质区域身份的指定是一个复杂的过程，由内在的皮质线索启动，并在来自丘脑的传入纤维到达后进行细化。关于这一过程的早期步骤的遗传控制知之甚少，但同源基因Emx 2在发育中的皮层中的独特表达模式促使人们提出它在这方面至关重要的建议。我们使用Emx 2（-/-）小鼠测试了这一假设。我们发现，正常频谱的皮质区域身份编码在这些突变体中，但与尾内侧身份的地区减少，与前外侧身份的皮质相对扩大。
The specification of area identities in the cerebral cortex is a complex process, primed by intrinsic cortical cues and refined after the arrival of afferent fibers from the thalamus. Little is known about the genetic control of the early steps of this process, but the distinctive expression pattern of the homeogene Emx2 in the developing cortex has prompted suggestions that it is critical in this context. We tested this hypothesis using Emx2(-/-) mice. We found that the normal spectrum of cortical areal identities was encoded in these mutants, but areas with caudal-medial identities were reduced and those with anterior-lateral identities were relatively expanded in the cortex.