Exploring cardiorespiratory control mechanisms through gas exchange dynamics.
Exploring cardiorespiratory control mechanisms through gas exchange dynamics.
复制标题
通过气体交换动力学探索心肺控制机制。
DOI：
10.1249/00005768-199002000-00012
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发表时间：
1990
影响因子：
4.1
通讯作者：
R. Hughson
中科院分区：
文献类型：
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作者：
R. Hughson
可以研究在工作率的阶跃变化开始时的摄氧量（VO 2）的增加速率，以提供关于控制该过程的生理机制的信息。几个系统必须相互作用才能产生总的响应。这些机制可分为氧运输和氧利用机制。在本文中，假设这些机制中的一个或另一个限制了VO 2的适应工作率的变化将被检查。除了传统的方法与工作率的阶跃变化，其他工作率强制功能的反应将被报告。这些包括斜坡、脉冲和伪随机二进制序列工作速率变化。从涉及从不同运动基线水平过渡的研究以及缺氧和β-肾上腺素能受体阻滞剂影响的研究中积累的证据得出结论，即氧转运机制限制了VO 2的增加速率。然而，VO 2在充足氧气存在下的动态响应与氧气限制条件下的动态响应没有太大不同。
The rate of increase in oxygen uptake (VO2) at the onset of a step change in work rate can be studied to provide information about the physiological mechanisms that control this process. Several systems must interact to produce the total response. These can be grouped into oxygen transport and oxygen utilization mechanisms. In this paper, the hypothesis that one or the other of these mechanisms limits the adaptation of VO2 to a change in work rate will be examined. In addition to the traditional approach with step changes in work rate, the responses to other work rate forcing functions will be reported. These include ramp, impulse, and pseudorandom binary sequence work rate changes. The evidence that is accumulating from studies involving transitions from different baseline levels of exercise, as well as studies of the effects of hypoxia and beta-adrenergic receptor blockade, has led to the conclusion that oxygen transport mechanisms limit the rate of increase in VO2. However, the dynamic response of VO2 in the presence of adequate oxygen is not much different from that of oxygen limited conditions.