The interaction between adriamycin and radiation in a solid murine tumor.
The interaction between adriamycin and radiation in a solid murine tumor.
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阿霉素和辐射在小鼠实体肿瘤中的相互作用。
DOI：
10.2307/3575285
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发表时间：
1980
影响因子：
3.4
通讯作者：
R. Sutherland
中科院分区：
文献类型：
--
作者：
D. Siemann;R. Sutherland
在EMT-6/Ro荷瘤BALB/cKa小鼠中研究了阿霉素和放射的单次和多次给药的组合。使用肿瘤生长延迟测定来确定对这些化学疗法-放射疗法治疗的响应。阿霉素和辐射之间的单次给药相互作用进行了评估，使用isoeffect分析，并被认为是添加剂之间的2小时和120小时的时间间隔时，肿瘤大小的变化占。当一个单一剂量，两个相等的剂量，或多个每日剂量的阿霉素（所有相同的总剂量）与10个200拉德的分数在12天内给予的过程相结合，所产生的肿瘤生长延迟也符合两种治疗方式之间的累加反应。然而，联合分次放疗，单次大剂量阿霉素比同时每日小剂量阿霉素暴露更有效。
Combinations of single and multiple doses of adriamycin and radiation were studied in EMT-6/Ro tumor-bearing BALB/cKa mice. The response to these chemotherapy-radiotherapy treatments was determined using a tumor growth delay assay. The single-dose interaction between adriamycin and radiation was assessed using an isoeffect analysis and was found to be additive for both a 2- and 120-hr interval between agents when changes in tumor size were accounted for. When a single dose, two equal doses, or multiple daily doses of adriamycin (all to the same total dose) were combined with a course of ten 200-rad fractions given in 12 days, the resultant tumor growth delays also were in keeping with an additive response between the two treatment modalities. However, in combination with fractionated radiotherapy, a large single dose of adriamycin was more effective than concurrent small daily adriamycin exposures.
体内肿瘤对阿霉素单次和多次暴露的反应。
影响因子：
8.4
作者：
Siemann,DW;Sutherland,RM
通讯作者：
Sutherland,RM
肿瘤大小：影响肿瘤对联合治疗方式反应的等效应分析的因素。
DOI：
--
发表时间：
1980
期刊：
The British journal of cancer. Supplement
影响因子：
--
作者：
Siemann,DW
通讯作者：
Siemann,DW