Interplay Between Right Ventricular Function and Cardiac Resynchronization Therapy An Analysis of the CARE-HF Trial (Cardiac Resynchronization-Heart Failure)
Interplay Between Right Ventricular Function and Cardiac Resynchronization Therapy An Analysis of the CARE-HF Trial (Cardiac Resynchronization-Heart Failure)
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DOI：
10.1016/j.jacc.2013.02.049
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发表时间：
2013-05-28
影响因子：
24
通讯作者：
Cleland, John G. F.
中科院分区：
文献类型：
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作者：
Damy, Thibaud;Ghio, Stefano;Cleland, John G. F.
目的 本研究的目的是调查参加 CARE-HF（心脏再同步-心力衰竭）试验的患者中心脏再同步治疗 (CRT) 对右心室 (RV) 功能的影响以及 RV 功能障碍对超声心动图和 CRT 临床反应的影响。 背景 心脏再同步治疗可延长适当选择的心力衰竭患者的生存期，但在 RV 功能障碍患者中获益可能会减少。 方法 纳入 813 名患者在 CARE-HF 研究中，688 名受试者在基线时测量了三尖瓣平面收缩期偏移 (TAPSE)，其中 345 名受试者被分配接受 CRT。他们的中位年龄（四分位距）为 66（58 至 71）岁，左心室（LV）射血分数为 24%（21% 至 28%），TAPSE 为 19（16 至 22）mm。 TAPSE 三分位数之间的基线 LV 功能、大小和 QRS 时限相似，但最差三分位数 (TAPSE
Objectives The aim of this study was to investigate the impact of cardiac resynchronization therapy (CRT) on right ventricular (RV) function and the influence of RV dysfunction on the echocardiographic and clinical response to CRT among patients enrolled in the CARE-HF (Cardiac Resynchronization-Heart Failure) trial.Background Cardiac resynchronization therapy prolongs survival in appropriately selected patients with heart failure but the benefit might be diminished in patients with RV dysfunction.Methods Of 813 patients enrolled in the CARE-HF study, 688 had tricuspid plane systolic excursion (TAPSE) measured at baseline, and 345 of these were assigned to CRT. Their median (interquartile range) age was 66 (58 to 71) years, left ventricular (LV) ejection fraction was 24% (21% to 28%), and TAPSE was 19 (16 to 22) mm. Baseline LV function and size and QRS duration were similar among TAPSE tertiles, but those in the worst tertile (TAPSE