Childhood correlates of blood lead levels in Mumbai and Delhi.
Childhood correlates of blood lead levels in Mumbai and Delhi.
复制标题
孟买和德里的血铅水平的儿童期相关。
DOI：
10.1289/ehp.8399
复制
发表时间：
2006-03
影响因子：
10.4
通讯作者：
Hu, Howard
中科院分区：
文献类型：
--
作者：
Jain, Nitin B;Hu, Howard
在一些国际研究中，铅暴露与儿童智力损伤有关。在印度，据报道，近一半的儿童血铅水平升高（BLL）。然而，对这些BLL升高的风险因素知之甚少。我们对1998-1999年进行的印度全国家庭健康调查的数据进行了回顾性横断面分析。我们评估了生活在印度孟买或德里的1,081名3岁以下儿童的BLL的潜在相关性。我们研究了年龄、性别、宗教、种姓、母亲的教育程度、生活水平、母乳喂养和体重/身高百分位数等因素。大多数儿童（76%）的BLL在5至20 μg/dL之间。在多元回归模型中，年龄、生活水平、体重/身高百分位数和母亲所生子女总数与BLL（对数转换）显著相关。与≤3月龄的儿童相比，4-11月龄和12-23月龄的儿童的BLL分别高出84%和146%（p < 0.001）。低生活水平与BLL增加32.3%相关（p = 0.02）。与体重/身高低于第5百分位数的儿童相比，体重/身高大于第95百分位数的儿童的BLL高31%（p = 0.03）。我们的研究发现各种因素与儿童BLL升高相关。大于第95百分位数的体重/身高与较高的BLL之间的相关性可能反映了铅暴露对身体形态的影响。我们的研究可能有助于针对易感人群，并确定孟买和德里BLL升高的可校正因素。
Lead exposure has previously been associated with intellectual impairment in children in a number of international studies. In India, it has been reported that nearly half of the children have elevated blood lead levels (BLLs). However, little is known about risk factors for these elevated BLLs. We conducted a retrospective cross-sectional analysis of data from the Indian National Family Health Survey, a population-based study conducted in 1998–1999. We assessed potential correlates of BLLs in 1,081 children who were < 3 years of age and living in Mumbai or Delhi, India. We examined factors such as age, sex, religion, caste, mother’s education, standard of living, breast-feeding, and weight/height percentile. Most children (76%) had BLLs between 5 and 20 μg/dL. Age, standard of living, weight/height percentile, and total number of children ever born to the mother were significantly associated with BLLs (log transformed) in multivariate regression models. Compared with children ≤3 months of age, children 4–11 and 12–23 month of age had 84 and 146% higher BLLs, respectively (p < 0.001). A low standard of living correlated with a 32.3% increase in BLLs (p = 0.02). Children greater than the 95th percentile for their weight/height had 31% (p = 0.03) higher BLLs compared with those who were below the 5th percentile for their weight/height. Our study found various factors correlated with elevated BLLs in children. The correlation between greater than the 95th percentile weight/height and higher BLL may reflect an impact of lead exposure on body habitus. Our study may help in targeting susceptible populations and identifying correctable factors for elevated BLLs in Mumbai and Delhi.