Effects of interleukin-1 and interleukin-1 receptor antagonist in AIDS-Kaposi's sarcoma.
Effects of interleukin-1 and interleukin-1 receptor antagonist in AIDS-Kaposi's sarcoma.
复制标题
白细胞介素 1 和白细胞介素 1 受体拮抗剂对艾滋病卡波西肉瘤的影响。
DOI：
10.1097/00042560-199504120-00004
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Gill,P
中科院分区：
文献类型：
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作者：
Louie,S;Cai,J;Law,R;Lin,G;Lunardi-Iskandar,Y;Jung,B;Masood,R;Gill,P
卡波西肉瘤(KS)是HIV-1感染患者中最常见的肿瘤。HIV-1可能通过病毒蛋白(S)直接诱导KS，也可能通过IL-1、IL-6等细胞因子的调节间接诱导KS。我们已经证明，AIDS-KS梭形细胞表达IL-1[β]，而IL-1ra抑制KS-梭形细胞生长。IL-1ra对人脐静脉内皮细胞(HUVEC)、人主动脉平滑肌细胞(HASM)和人包皮成纤维细胞(NN41)作用不明显。这些发现支持IL-1的自分泌活性。此外，外源性IL-1可促进AIDS-KS细胞的生长，这种作用可被IL-1ra完全阻断。正如预期的那样，IL-1ra还阻断了IL-1介导的IL-6和bFGF的上调，这两种细胞都是KS的自分泌生长因子。因此，IL-1ra是治疗艾滋病相关KS的潜在候选药物。
Kaposi's sarcoma (KS) is the most common tumor seen in patients with HIV-1 infection. HIV-1 may induce KS directly through viral protein (s) or indirectly through regulation of cytokines such as IL-1 and IL-6. We have shown that AIDS-KS spindle cells express IL-1 [beta] and that IL-1ra inhibits KS-spindle cell growth. IL-1ra had little effect on human umbilical vein endothelial cells (HUVEC), human aortic smooth muscle cells (HASM), and human foreskin fibroblast (NN41). These findings support an autocrine activity for IL-1. Furthermore, exogenous IL-1 can enhance AIDS-KS cell growth, and this effect is completely blocked by IL-1ra. As expected, IL-1ra also blocks IL-1 mediated upregulation of IL-6 and bFGF, both of which are autocrine growth factors for KS. IL-1ra is thus a potential candidate for the treatment of AIDS-associated KS.