Comparison of ASDAS and BASDAI as a measure of disease activity in axial psoriatic arthritis
Comparison of ASDAS and BASDAI as a measure of disease activity in axial psoriatic arthritis
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DOI：
10.1007/s10067-014-2734-8
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发表时间：
2015-03-01
影响因子：
3.4
通讯作者：
Ozgocmen, Salih
中科院分区：
文献类型：
--
作者：
Kilic, Gamze;Kilic, Erkan;Ozgocmen, Salih
本研究的目的是比较强直性脊柱炎疾病活动性评分(ASDAS)与Bath强直性脊柱炎疾病活动性指数(BASDAI)及其他临床疾病活动性指标在轴性银屑病关节炎(AxPsA)患者中的区分能力。AxPsA患者来自Erciyes Spondylotis Cohort(ESPAC)和Anatolian Group for the Eheumatic疾病评估(ANGARD)队列，并接受BASDAI、ASDAS、BASFI(巴斯强直性脊柱炎功能指数)、强直性脊柱炎生活质量(ASQOL)和视觉模拟评分(VAS)疼痛的评估。采用标准化均数差法评价ASDAS-C-反应蛋白(-CRP)和ASDAS-血沉(-ESR)在疾病活动度高低之间的判别能力。54名axPsA患者被纳入研究。两种ASDAS评分均显示出良好的疾病活跃度高低的区分能力。在受试者工作特征(ROC)曲线分析中，根据部分缓解、患者和医生的总体评估，ASDAS版本和BASDAI都有相对较高的曲线下面积(AUC)。对于ASDAS-CRP和ASDAS-ESR与BASDAI进行比较的模型，对于每个疾病活动状态的单独定义，AUC评分之间没有显著差异。在axPsA的AUC分析中，ASDAS版本和BASDAI显示出很好的相似的区分高和低疾病活动的能力。非活动性疾病和高活动性疾病的临界值与AS的预定义临界值相对相似。此外，现在需要进行前瞻性验证，以确定适当的评估工具和axPsA中的分界值。
The aim of this study was to compare the discriminative ability of Ankylosing Spondylitis Disease Activity Score (ASDAS) with Bath Ankylosing Spondylitis Activity Disease Activity Index (BASDAI) and other clinical disease activity parameters in patients with axial psoriatic arthritis (axPsA). Patients with axPsA were recruited from Erciyes Spondyloarthritis Cohort (ESPAC) and Anatolian Group for the Assessment in Rheumatic Disease (ANGARD) cohort and were assessed for BASDAI, ASDAS, BASFI (Bath Ankylosing Spondylitis Functional Index), Ankylosing Spondylitis Quality of Life (ASQoL), and visual analog scale (VAS) pain. The discriminant ability of ASDAS-C-reactive protein (-CRP) and ASDAS-erythrocyte sedimentation rate (-ESR) was assessed using standardized mean differences between patients with high and low disease activity. Fifty-four patients with axPsA were included in the study. Both ASDAS scores showed good discriminative ability between high and low disease activity states. Both ASDAS versions and BASDAI had relatively high area under the curve (AUC) according to ASAS partial remission, patient and physician global assessments in receiver operating characteristic (ROC) curve analysis. There was no significant difference between AUC scores for the models that compared ASDAS-CRP and ASDAS-ESR with BASDAI for each individual definition of disease activity states. ASDAS versions and BASDAI showed good similar discriminative ability between high and low disease activity as reflected by the AUC analysis in axPsA. The cutoff values for inactive disease and high disease activity were relatively similar to predefined cutoff values for AS. Further, prospective validation is now required to identify the appropriate assessment tools and cutoff values in axPsA.