Visceral obesity and metabolic syndrome.
Visceral obesity and metabolic syndrome.
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DOI：
10.1046/j.1467-789x.2000.00008.x
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发表时间：
2000-05-01
期刊：
影响因子：
--
通讯作者：
Zamboni, M
中科院分区：
文献类型：
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作者：
Bosello, O;Zamboni, M
越来越多的证据表明存在一种由一系列代谢紊乱组成的疾病，包括胰岛素抵抗、葡萄糖和脂质代谢的改变、血压升高和内脏肥胖。代谢综合征现在是该簇的首选定义。该簇中的每一个组成部分都会增加心血管风险，但因素的组合更为重要。胰岛素抵抗是与该综合征的单一成分最常见的相关因素：大多数作者认为它可能是常见的病因。然而，内脏肥胖似乎是主要驱动因素，因为游离脂肪酸的产生增加，而游离脂肪酸的活性反过来可能会干扰胰岛素的作用。由于该综合征经常缺乏其中一个因素，因此存在一些关于该综合征的问题。这并不意味着缺失的因素不属于该综合征，而只是表示临床上尚不明显。体重增加已被证明是代谢综合征的有力预测因素。这一方面为治疗和预防提供了力量，因为这意味着减肥或停止体重增加可能会降低未来出现仍不明显的因素的风险。通过减肥来治疗内脏肥胖的干预措施似乎是治疗代谢综合征的最有效方法，从而改善西方国家最普遍的心血管危险因素。
There is increasing evidence for the existence of a condition consisting of a cluster of metabolic disorders which include insulin resistance, alterations in glucose and lipid metabolism, increased blood pressure and visceral obesity. The metabolic syndrome is now the favoured definition of the cluster. Each single component of the cluster increases the cardiovascular risk, but the combination of factors is much more important. Insulin resistance is the most frequently associated factor to the singular components of the syndrome: most authors believe that it may be the common aetiological factor. However, visceral obesity seems to be the main driving factor by means of the increased production of free fatty acids whose activity, in turn, might interfere with the action of insulin. Some questions exist about the syndrome because of the frequent lack in the cluster of one of the factors. This does not mean that the missing factor does not belong to the syndrome, but only that it is not yet clinically evident. Weight gain has been shown to be a strong predictor of the metabolic syndrome. This aspect gives strength to treatment and prevention because it means that losing weight or stopping weight increase might reduce the risk of a future appearance of a factor that is still not evident. Interventions to treat visceral obesity by means of losing weight seem to be the most efficacious way to treat the metabolic syndrome thus improving the most widespread cardiovascular risk factor in western countries.