Junctional Music that the Nucleus Hears: Cell-Cell Contact Signaling and the Modulation of Gene Activity
Junctional Music that the Nucleus Hears: Cell-Cell Contact Signaling and the Modulation of Gene Activity
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DOI：
10.1101/cshperspect.a002923
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发表时间：
2009-10-01
影响因子：
7.2
通讯作者：
Balda, Maria S.
中科院分区：
文献类型：
--
作者：
McCrea, Pierre D.;Gu, Dongmin;Balda, Maria S.
细胞-细胞连接继续吸引细胞和发育生物学家的兴趣，其中一个新兴领域是连接信号与细胞核中基因活性相关的分子手段。虽然在确定这种信号转导的直接与间接性质时经常出现复杂性，但很明显，这种途径对组织的功能至关重要，并且改变可能导致许多病理结果。这篇综述评估了各种细胞连接到核信号通路，并概述了进一步研究的有趣领域。
Cell-cell junctions continue to capture the interest of cell and developmental biologists, with an emerging area being the molecular means by which junctional signals relate to gene activity in the nucleus. Although complexities often arise in determining the direct versus indirect nature of such signal transduction, it is clear that such pathways are essential for the function of tissues and that alterationsmay contribute to many pathological outcomes. This review assesses a variety of cell-cell junction-to-nuclear signaling pathways, and outlines interesting areas for further study.