Glycolipids in mammalian epidermis: structure and function in the water barrier.
Glycolipids in mammalian epidermis: structure and function in the water barrier.
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哺乳动物表皮中的糖脂：水屏障中的结构和功能。
DOI：
10.1126/science.7112128
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Downing,DT
中科院分区：
文献类型：
--
作者：
Wertz,PW;Downing,DT
在陆生脊椎动物的表皮中，角质层细胞之间的脂质层被认为是防止水分流失的屏障。脂质在层状颗粒中组装后从活细胞中挤出。最近发现的1-（3′- o -酰基）-β- d -葡萄糖基- n -（ω-羟基酰基）鞘烷可能促进了这种组装，这些鞘烷含有30碳和32碳的羟基酸作为酰胺和亚油酸酯化成葡萄糖。这些分子的这种作用可以解释必需脂肪酸缺乏的影响，在这种情况下，片层颗粒无法组装，水扩散的屏障丧失。
In the epidermis of terrestrial vertebrates, lipid lamellae between the horny cells are thought to form a barrier to water loss. The lipids are extruded from living cells after assembly in lamellar granules. This assembly might be promoted by recently identified 1-(3′-O-acyl)-β-D-glucosyl-N-(ω-hydroxyacyl)sphingosines, which have 30- and 32-carbon hydroxy acids as amides and linoleic acid esterified to glucose. Such a role for these molecules could explain the effects of essential fatty acid deficiency, in which the lamellar granules fail to assemble and the barrier to water diffusion is lost.