Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus.
Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus.
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聚（a）结合蛋白1增强了来自禽疱疹病毒的神经电动性因子的帽非依赖性翻译起始。
DOI：
10.1371/journal.pone.0114466
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Nair V
中科院分区：
文献类型：
--
作者：
Tahiri-Alaoui A;Zhao Y;Sadigh Y;Popplestone J;Kgosana L;Smith LP;Nair V
Poly(A) binding protein 1 (PABP1) plays a central role in mRNA translation and stability and is a target by many viruses in diverse manners. We report a novel viral translational control strategy involving the recruitment of PABP1 to the 5' leader internal ribosome entry site (5L IRES) of an immediate-early (IE) bicistronic mRNA that encodes the neurovirulence protein (pp14) from the avian herpesvirus Marek’s disease virus serotype 1 (MDV1). We provide evidence for the interaction between an internal poly(A) sequence within the 5L IRES and PABP1 which may occur concomitantly with the recruitment of PABP1 to the poly(A) tail. RNA interference and reverse genetic mutagenesis results show that a subset of virally encoded-microRNAs (miRNAs) targets the inhibitor of PABP1, known as paip2, and therefore plays an indirect role in PABP1 recruitment strategy by increasing the available pool of active PABP1. We propose a model that may offer a mechanistic explanation for the cap-independent enhancement of the activity of the 5L IRES by recruitment of a bona fide initiation protein to the 5' end of the message and that is, from the affinity binding data, still compatible with the formation of ‘closed loop’ structure of mRNA.
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影响因子：
5.4
作者：
Kerekatte, V;Keiper, BD;Rhoads, RE
通讯作者：
Rhoads, RE
通过病毒发育开关激活宿主翻译控制途径。
影响因子：
6.7
作者：
Arias C;Walsh D;Harbell J;Wilson AC;Mohr I
通讯作者：
Mohr I
影响因子：
14.9
作者：
Afonina ZA;Myasnikov AG;Shirokov VA;Klaholz BP;Spirin AS
通讯作者：
Spirin AS
影响因子：
4.8
作者：
Melo, EO;Dhalia, R;Neto, OPD
通讯作者：
Neto, OPD
DOI：
10.1073/pnas.0706295104
发表时间：
2007-12-11
影响因子：
11.1
作者：
Jarosinski, Keith;Kattenhorn, Lisa;Osterrieder, Nikolaus
通讯作者：
Osterrieder, Nikolaus