Welcoming back my arm: affective touch increases body ownership following right-hemisphere stroke
Welcoming back my arm: affective touch increases body ownership following right-hemisphere stroke
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DOI：
10.1093/braincomms/fcaa034
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发表时间：
2020-01-01
影响因子：
4.8
通讯作者：
Fotopoulou, Aikaterini
中科院分区：
文献类型：
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作者：
Jenkinson, Paul M.;Papadaki, Cristina;Fotopoulou, Aikaterini
右半球中风会削弱一个人将对侧身体部位识别为属于自己的能力。对这种所谓的“肢体所有权错乱感”的研究可以为身体所有权的神经认知机制提供独特的见解。在这项研究中，我们提出了一个建立在健康志愿者身体所有权实验研究基础上的假说。这些研究表明，情感(愉悦)触摸，一种与无髓鞘、缓慢传导的C-触觉传入相关的感觉间通道，在身体所有权意识中具有独特的作用。在这项研究中，我们系统地研究了情感触摸刺激是否可以增加右半球中风后肢体所有权意识紊乱的患者的身体所有权。对16名急性卒中成人患者进行的初步可行性研究使我们能够优化和校准床边实施的情感触摸方案。主要的实验是对26名右半球患者进行的不同样本，评估了自我(患者)和他人(实验者)产生触觉刺激后肢体所有权的变化，使用了已知最有利于激活C-触觉纤维的速度(即3厘米/S)和次佳的C-触觉激活速度(即18厘米/S)。我们在第二次分析中进一步考察了观察到的肢体所有权变化的特异性和机制，考察了(I)触摸的感知强度和愉悦感的影响，(Ii)触摸的偏侧性，(Iii)肢体所有权的混乱程度对所有权变化的影响，以及(Iv)触摸引起的单侧忽视的变化。研究结果表明，在实验人员管理的C-触觉最佳触摸之后，肢体所有权显著增加。基于体素的损伤-症状映射发现了右脑岛的损伤，更实质的是，右胼胝体的损伤，与实验者管理的情感触摸后未能增加身体所有权有关。我们的发现表明，情感触摸可以增加右半球中风后身体部位的归属感，这可能是因为它在构成身体归属感的多感觉整合过程中扮演着独特的角色。
Right-hemisphere stroke can impair the ability to recognize one's contralesional body parts as belonging to one's self. The study of this so-called `disturbed sense of limb ownership' can provide unique insights into the neurocognitive mechanisms of body ownership. In this study, we address a hypothesis built upon experimental studies on body ownership in healthy volunteers. These studies have shown that affective (pleasant) touch, an interoceptive modality associated with unmyelinated, slow-conducting C-tactile afferents, has a unique role in the sense of body ownership. In this study, we systematically investigated whether affective touch stimulation could increase body ownership in patients with a disturbed sense of limb ownership following right-hemisphere stroke. An initial feasibility study in 16 adult patients with acute stroke enabled us to optimize and calibrate an affective touch protocol to be administered by the bedside. The main experiment, conducted with a different sample of 26 right hemisphere patients, assessed changes in limb ownership elicited following self- (patient) versus other- (experimenter) generated tactile stimulation, using a velocity known to optimally activate C-tactile fibres (i.e. 3 cm/s), and a second velocity that is suboptimal for C-tactile activation (i.e. 18 cm/s). We further examined the specificity and mechanism of observed changes in limb ownership in secondary analyses looking at (i) the influence of perceived intensity and pleasantness of touch, (ii) touch laterality and (iii) level of disturbed sense of limb ownership on ownership change and (iv) changes in unilateral neglect arising from touch. Findings indicated a significant increase in limb ownership following experimenter-administered, C-tactile-optimal touch. Voxel-based lesion-symptom mapping identified damage to the right insula and, more substantially, the right corpus callosum, associated with a failure to increase body ownership following experimenter-administered, affective touch. Our findings suggest that affective touch can increase the sense of body-part ownership following right-hemisphere stroke, potentially due to its unique role in the multisensory integration processes that underlie the sense of body ownership.