Gene-Environment Interactions in Depression Research: Genetic Polymorphisms and Life-Stress Polyprocedures
Gene-Environment Interactions in Depression Research: Genetic Polymorphisms and Life-Stress Polyprocedures
复制标题
DOI：
10.1111/j.1467-9280.2008.02181.x
复制
发表时间：
2008-10-01
影响因子：
8.2
通讯作者：
Reid, Mark W.
中科院分区：
文献类型：
--
作者：
Monroe, Scott M.;Reid, Mark W.
最近关于生活压力、抑郁症和血清素转运蛋白基因 (5-HTTLPR) 启动子区域多态性的研究以强大的遗传技术为特点，但也以非常规和不一致的评估生活压力的方法为特点。本综述通过批判性地评估这些快速增长的文献来解决这个问题，这些文献涉及用于评估生活压力的概念和程序以及用于测试因果关系的研究设计。由于测量生活压力的临时方法占主导地位，并且缺乏对研究设计关键问题的关注，现有证据受到严重损害。概述了更精细和更严格的压力测量的原则和程序。需要改进的指南来指导未来关于生活压力和基因在精神病理学、病理生理过程和疾病中的相互作用影响的研究。
Recent studies on life stress, depression, and polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) are characterized by powerful genetic techniques, but are also characterized by unconventional and inconsistent approaches to assessing life stress. The present review addresses this problem by critically evaluating this rapidly growing literature with regard to the concepts and procedures employed to assess life stress and the research designs used to test causal associations. The existing body of evidence is seriously compromised by the predominance of ad hoc approaches for measuring life stress and by a lack of attention to key issues concerning research design. Principles and procedures for more refined and rigorous stress measurement are outlined. Improved guidelines are needed to direct future research on interactive effects of life stress and genes in psychopathology, pathophysiological processes, and disease.