The pathogenesis of autoimmunity in New Zealand mice.
The pathogenesis of autoimmunity in New Zealand mice.
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DOI：
10.1016/0049-0172(90)90002-w
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发表时间：
1990-02
影响因子：
5
通讯作者：
A. Borchers;A. Ansari;T. Hsu;D. Kono;M. Gershwin
中科院分区：
文献类型：
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作者：
A. Borchers;A. Ansari;T. Hsu;D. Kono;M. Gershwin
免疫系统的结构和功能的核心主题是自我/非自我辨别。这种功能是细胞间合作进化和多细胞和群体生命形式发展的关键因素。事实上，现存的海洋无脊椎动物的识别系统让人想起遥远的过去。在哺乳动物的免疫反应中，这种特性已经达到了最复杂的程度。通过相互关联的途径网络，免疫系统对活体或非活体异物的入侵做出反应，并做出适当的反应，从宿主动物中消除。生成和维护入侵实体的性质的记录的能力也导致对后续接触的更快反应。一个复杂的网络需要众多的制衡点才能正常运作;这本身就为系统的不平衡提供了许多机会。很少有疾病能像系统性红斑狼疮（SLE）那样清楚地证明这一点，在这种疾病中，免疫系统失去了区分异物和自身的能力。在这方面，自身免疫性疾病的小鼠模型有助于理解这种疾病。尽管在过去的30年中已经产生了大量描述这些小鼠的许多体液和细胞异常的数据，但疾病的主要原因尚未确定。澄清他们的疾病的病因的问题一直很大
T HE CENTRAL THEME underlying the structure and function of the immune system is self/nonself discrimination. This function was a crucial factor in the evolution of intercellular cooperation and the development of multicellular and colonial life forms. Indeed, extant marine invertebrates have recognition systems reminiscent of those of the distant past. In the mammalian immune response this property has reached its greatest complexity. Through a network of interrelated pathways, the immune system responds to the intrusion of living or nonliving foreign matter with an appropriate response directed toward elimination from the host animal. The capacity to generate and maintain a record of the nature of the invading entity also results in faster responses to subsequent contacts. A complex network needs numerous sites of checks and balances to function properly; inherently, this presents many opportunities for imbalances in the system. Few conditions demonstrate this as clearly as systemic lupus erythematosus (SLE), in which the immune system loses its ability to distinguish foreign material from self. In this regard, murine models of autoimmune disease has been helpful in the understanding of this illness.’Although significant volumes of data describing the many humoral and cellular anomalies of these mice have been generated in the past 3 decades, the primary cause of disease has yet to be determined. The problems of clarifying the etiology of their disorders have been great