STAGE-DEPENDENT INHIBITION OF CHLOROQUINE ON PLASMODIUM-FALCIPARUM INVITRO
STAGE-DEPENDENT INHIBITION OF CHLOROQUINE ON PLASMODIUM-FALCIPARUM INVITRO
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DOI：
10.2307/3281830
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发表时间：
1986-12-01
影响因子：
1.3
通讯作者：
JUNG, A
中科院分区：
文献类型：
--
作者：
YA, Z;ASANTE, KSO;JUNG, A
为确定氯喹对恶性疟原虫不同阶段生长的影响，对恶性疟原虫在高度同步培养条件下，分别在环期、滋养体期和裂殖期暴露于治疗性浓度氯喹后的生活史进行了形态观察。结果发现，氯喹不影响裂殖子对红细胞的侵袭；环期对氯喹的敏感性高于滋养体和裂殖体阶段；治疗浓度的氯喹仅阻止环状向滋养体的转化，而不影响滋养体向裂殖体和裂殖体向新环的转化。氯喹的IC_(50)测定表明，滋养体的IC_(50)约为环的6倍。
Morphological observation of the life cycle of the malaria parasite, Plasmodium falciparum, in highly synchronous cultures after an exposure to therapeutic concentrations of chloroquine in ring, trophozoite and schizont stages, respectively, were carried out in order to determine the influence of chloroquine on the growth of the different stages of the malarial parasites. It was found that chloroquine could not affect merozoite invasion of the erythrocytes; the ring stage was more sensitive to chloroquine than the trophozoite and schizont stages; and chloroquine in therapeutic concentrations prevented only the transformation of rings to trophozoites and could not affect the transformations of trophozoites to schizonts and schizonts to new rings. The determination of the IC50 of chloroquine showed that the IC50 of trophozoites was about 6 times as high as that of rings.