Oxidative stress and autophagy: the clash between damage and metabolic needs.
Oxidative stress and autophagy: the clash between damage and metabolic needs.
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DOI：
10.1038/cdd.2014.150
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发表时间：
2015-03
影响因子：
12.4
通讯作者：
中科院分区：
文献类型：
--
作者：
自噬是一种分解代谢过程，旨在回收细胞组分和受损的细胞器，以响应不同的应激条件，如营养剥夺，病毒感染和遗传毒性应激。近年来，越来越多的证据表明氧化应激是这些刺激的汇聚点，活性氧（ROS）和活性氮（RNS）是维持自噬的主要细胞内信号转导分子。本文综述了葡萄糖和氨基酸剥夺对自噬的调控途径及其与代谢网络和氧化还原稳态的紧密联系。氧化和亚硝化应激在自噬中的作用也进行了讨论，其是有害的细胞生物分子和信号介质，通过可逆的翻译后修饰的含巯基的蛋白质。通过p62/Keap 1/Nrf 2途径发生的自噬和抗氧化反应之间的氧化还原独立关系也得到了解决，以提供自噬和氧化应激之间相互联系的广泛视角。在此，我们还试图提供一个概述的复杂的串扰之间的自噬和DNA损伤反应（DDR），集中在激活的主要途径后，ROS和RNS过度生产。沿着这些路线，直接和间接的自噬作用在DDR深入剖析。
Autophagy is a catabolic process aimed at recycling cellular components and damaged organelles in response to diverse conditions of stress, such as nutrient deprivation, viral infection and genotoxic stress. A growing amount of evidence in recent years argues for oxidative stress acting as the converging point of these stimuli, with reactive oxygen species (ROS) and reactive nitrogen species (RNS) being among the main intracellular signal transducers sustaining autophagy. This review aims at providing novel insight into the regulatory pathways of autophagy in response to glucose and amino acid deprivation, as well as their tight interconnection with metabolic networks and redox homeostasis. The role of oxidative and nitrosative stress in autophagy is also discussed in the light of its being harmful for both cellular biomolecules and signal mediator through reversible posttranslational modifications of thiol-containing proteins. The redox-independent relationship between autophagy and antioxidant response, occurring through the p62/Keap1/Nrf2 pathway, is also addressed in order to provide a wide perspective upon the interconnection between autophagy and oxidative stress. Herein, we also attempt to afford an overview of the complex crosstalk between autophagy and DNA damage response (DDR), focusing on the main pathways activated upon ROS and RNS overproduction. Along these lines, the direct and indirect role of autophagy in DDR is dissected in depth.
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DOI：
10.1158/1541-7786.mcr-11-0098
发表时间：
2011-09
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Bae H;Guan JL
通讯作者：
Guan JL
影响因子：
16
作者：
Ciccia A;Elledge SJ
通讯作者：
Elledge SJ
影响因子：
--
作者：
Di Giacomo G;Rizza S;Montagna C;Filomeni G
通讯作者：
Filomeni G
影响因子：
50.3
作者：
Degenhardt, Kurt;Mathew, Robin;White, Eileen
通讯作者：
White, Eileen
DOI：
10.1073/pnas.1218065109
发表时间：
2013-01-02
影响因子：
11.1
作者：
Dotiwala, Farokh;Eapen, Vinay V.;Haber, James E.
通讯作者：
Haber, James E.