Nationwide Epidemiological Survey of Autoimmune Pancreatitis in Japan
Nationwide Epidemiological Survey of Autoimmune Pancreatitis in Japan
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DOI：
10.1097/mpa.0b013e3182480c99
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发表时间：
2012-08-01
期刊：
影响因子：
2.9
通讯作者：
Shimosegawa, Tooru
中科院分区：
文献类型：
--
作者：
Kanno, Atsushi;Nishimori, Isao;Shimosegawa, Tooru
目的：为了阐明日本自身免疫性胰腺炎（AIP）的临床流行病学特征，在全国范围内进行了调查。根据2006年日本临床诊断标准诊断为自身免疫性胰腺炎。该研究包括两个阶段的调查：与AIP患者的人数估计的第一个问卷和他们的临床特征进行了评估的第二questionnaire.Results：估计的总人数AIP患者在2007年为2790（95%置信区间，2540-3040），与总患病率为2.2每10万人口。新诊断为AIP的患者数量估计为1120例（95%置信区间为1000-1240），年发病率为0.9/100，000人群。性别比（男/女）为3.7，平均（SD）年龄为63.0（11.4）岁。在546例患者的临床资料，87.6%的患者出现高血清免疫球蛋白G4水平（>= 135 mg/dL），和83%接受类固醇therapy.Conclusions：数据代表了目前的AIP在日本的临床特征。从结果来看，根据AIP的最新分类，日本的大多数AIP患者可被归类为1型AIP。
Objectives: To clarify the clinicoepidemiological features of autoimmune pancreatitis (AIP) in Japan, the nationwide survey was conducted.Methods: Patients with AIP who had visited the selected hospitals in 2007 were surveyed. Autoimmune pancreatitis was diagnosed according to the Japanese clinical diagnostic criteria 2006. The study consisted of 2-stage surveys: the number of patients with AIP was estimated by the first questionnaire and their clinical features were assessed by the second questionnaire.Results: The estimated total number of AIP patients in 2007 was 2790 (95% confidence interval, 2540-3040), with an overall prevalence rate of 2.2 per 100,000 populations. The number of patients, who were newly diagnosed as AIP, was estimated to be 1120 (95% confidence interval, 1000-1240), with an annual incidence rate of 0.9 per 100,000 populations. Sex ratio (male to female) was 3.7, and the mean (SD) age was 63.0 (11.4) years. Among the 546 patients whose clinical information was obtained, 87.6% of the patients presented high serum immunoglobulin G4 levels (>= 135 mg/dL), and 83% received steroid therapy.Conclusions: The data represent the current clinical features of AIP in Japan. From the results, most AIP patients in Japan can be categorized to type 1 AIP according to the recent classification of AIP.