Capsaicin depletes corticotropin-releasing factor-like immunoreactive neurons in the rat spinal cord and medulla oblongata.
Capsaicin depletes corticotropin-releasing factor-like immunoreactive neurons in the rat spinal cord and medulla oblongata.
复制标题
辣椒素消耗大鼠脊髓和延髓中促肾上腺皮质激素释放因子样免疫反应性神经元。
DOI：
10.1159/000123942
复制
发表时间：
1984
影响因子：
4.1
通讯作者：
Jacobowitz,DM
中科院分区：
文献类型：
--
作者：
Skofitsch,G;Hamill,GS;Jacobowitz,DM
用辣椒素治疗新生大鼠可导致脊髓背角（板层I和II）、三叉神经脊束核和束、孤束核中促肾上腺皮质激素释放因子免疫反应性神经纤维消失，但正中隆起和杏仁中央核中未出现。众所周知，辣椒素选择性地作用于C纤维类型的初级感觉神经元，因此建议促肾上腺皮质激素释放因子也位于外周感觉神经元中，代表一种新型肽能神经元系统，可能参与外周伤害性冲动的调节或传递，这与辣椒素耐药的下丘脑漏斗状部促肾上腺皮质激素释放因子系统不同。
Treatment of newborn rats with capsaicin was shown to cause a disappearance of corticotropin-releasing factor immunoreactive nerve fibers in the dorsal horn of the spinal cord (laminae I and II), the spinal trigeminal nucleus and tract, and the nucleus tractus solitarius, but not in the median eminence and the nucleus amygdaloideus centralis. Since it is well known that capsaicin acts selectively on primary sensory neurons of the C-fiber type, it is suggested that corticotropin-releasing factor is also located in peripheral sensory neurons, representing a novel peptidergic neuronal system, possibly involved in the modulation or transmission of peripheral nociceptive impulses, which is different from the capsaicin-resistant hypothalamoinfundibular corticotropin-releasing factor system.