A multi-channel high time resolution detector for high content imaging
A multi-channel high time resolution detector for high content imaging
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DOI：
10.1016/j.nima.2009.05.194
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发表时间：
2009-10-21
影响因子：
1.4
通讯作者：
Milnes, J.
中科院分区：
文献类型：
--
作者：
Lapington, J. S.;Fraser, G. W.;Milnes, J.
长期以来，医学成像一直受益于空间和粒子物理学带来的光子计数探测器的进步。我们描述了一种基于微通道板的高含量(多参数)分析探测器系统，该系统专门设计用于为成像活细胞和组织中的测量提供阶梯变化的性能和吞吐量。探测器系统将多通道、高时间分辨率、光子计数能力集成到单个集成ASIC电子设备的小型化探测器中，包括一个快速、低功耗的放大器鉴别器和用于离散像素电子读出的每个通道的TDC，与现有的同类器件相比，像素密度提高了两个数量级。该器件在紧凑的占地面积内集高性能、易重新配置和经济性于一身。我们提供了模拟和初步测量的背景下，我们的最终目标是20ps的时间分辨率和多通道并行分析(1024通道)。(C)2009爱思唯尔B.V.保留所有权利。
Medical imaging has long benefited from advances in photon counting detectors arising from space and particle physics. We describe a microchannel plate-based detector system for high content (multi-parametric) analysis, specifically designed to provide a step change in performance and throughput for measurements in imaged live cells and tissue for the 'omics'.The detector system integrates multi-channel, high time resolution, photon counting capability into a single miniaturized detector with integrated ASIC electronics, comprising a fast, low power amplifier discriminator and TDC for every channel of the discrete pixel electronic readout, and achieving a pixel density improvement of order two magnitudes compared with current comparable devices. The device combines high performance, easy reconfigurability, and economy within a compact footprint. We present simulations and preliminary measurements in the context of our ultimate goals of 20 ps time resolution with multi-channel parallel analysis (1024 channels). (C) 2009 Elsevier B.V. All rights reserved.