B7-1 AND B7-2 DO NOT DELIVER IDENTICAL COSTIMULATORY SIGNALS, SINCE B7-2 BUT NOT B7-1 PREFERENTIALLY COSTIMULATES THE INITIAL PRODUCTION OF IL-4
B7-1 AND B7-2 DO NOT DELIVER IDENTICAL COSTIMULATORY SIGNALS, SINCE B7-2 BUT NOT B7-1 PREFERENTIALLY COSTIMULATES THE INITIAL PRODUCTION OF IL-4
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DOI：
10.1016/1074-7613(95)90032-2
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发表时间：
1995-05-01
期刊：
影响因子：
32.4
通讯作者：
NADLER, LM
中科院分区：
文献类型：
--
作者：
FREEMAN, GJ;BOUSSIOTIS, VA;NADLER, LM
目前还不清楚两种CD 28反受体（B7-1和B7-2）的功能必要性。B7-1和B7-2等效地共刺激IL-2和干扰素-γ（IFN γ）产生以及IL-2受体α和γ链表达。B7-2比B7-1诱导显著更多的IL-4产生，其中在初始T细胞中观察到最大差异。用B7-2重复共刺激CD 4（+）CD 45 RA（+）T细胞导致中等水平的IL-4和IL-2，而用B7-1重复共刺激导致高水平的IL-2和低水平的IL-4。因此，B7-1和B7-2共刺激介导不同的结果，因为B7-2提供了诱导初始T细胞成为IL-4生产者的初始信号，从而将免疫应答更多地导向Th 0/Th 2，而B7-1是更中性的分化信号。
The functional necessity for two CD28 counterreceptors (B7-1 and B7-2) is presently unknown. B7-1 and B7-2 equivalently costimulate IL-2 and interferon-gamma (IFN gamma) production and IL-2 receptor alpha and gamma chain expression. B7-2 induces significantly more IL-4 production than B7-1, with the greatest difference seen in naive T cells. Repetitive costimulation of CD4(+) CD45RA(+) T cells with B7-2 results in moderate levels of both IL-4 and IL-2, whereas repetitive costimulation with B7-1 results in high levels of IL-2 and low levels of IL-4. Therefore, B7-1 and B7-2 costimulation mediate distinct outcomes, since B7-2 provides an initial signal to induce naive T cells to become IL-4 producers, thereby directing the immune response more towards Th0/Th2, whereas B7-1 is a more neutral differentiative signal.