Stimulant-induced psychosis and schizophrenia: the role of sensitization.
Stimulant-induced psychosis and schizophrenia: the role of sensitization.
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DOI：
10.1007/s11920-002-0024-7
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发表时间：
2002-06-01
影响因子：
6.7
通讯作者：
Ujike, Hiroshi
中科院分区：
文献类型：
--
作者：
Ujike, Hiroshi
在三种不同的情况下，精神刺激剂诱导的啮齿类动物的行为敏感化、人类的精神刺激剂诱导的精神病和慢性精神分裂症显示出相似的纵向变化，逐渐增加对异常行为、精神状态和复发的易感性。对药物或内源性多巴胺的敏化现象应参与这种敏感性的发生机制。最近，精神分裂症患者通过纹状体注射苯丙胺可以促进体内多巴胺的释放，这是先前在大鼠行为敏化方面所证明的结果。因此，敏化现象的共同分子机制必须在这三种条件下形成，本文对此作一综述。
Three different conditions, psychostimulant-induced behavioral sensitization in rodents, psychostimulant-induced psychoses in human, and chronic schizophrenia show similar longitudinal alternations, progressively enhanced susceptibility to abnormal behaviors, psychotic state, and relapse. Sensitization phenomena to the drugs or endogenous dopamine should be involved in the mechanisms underlying the development of such susceptibility. Recently, an enhanced dopamine release in vivo by amphetamine administration in the striatum has been shown in schizophrenics, which is a replication of that previously proven in the behavioral sensitization in rats. Accordingly, common molecular mechanisms of sensitization phenomena must develop in these three conditions, and are overviewed in this review