A randomized, double-blind, controlled trial of vitamin C in the management of hypertension and lipids.
A randomized, double-blind, controlled trial of vitamin C in the management of hypertension and lipids.
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DOI：
10.1097/00045391-200207000-00005
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发表时间：
2002-07-01
影响因子：
4.2
通讯作者：
Kochar, Mahendr S
中科院分区：
文献类型：
--
作者：
Hajjar, Ihab M;George, Varghese;Kochar, Mahendr S
维生素C对血压的影响还没有得到很好的证实。这是一项随机、双盲对照试验。符合条件的患者随访8个月。患者随机接受500、1000或2000 mg维生素C治疗。在每次访视期间，获得包括药物变化在内的病史，并进行标准化血压测量。每次访视前填写1周饮食日记。采用多元回归分析和随后的多重比较进行数据分析。54例患者符合我们的标准并同意参与。31名患者（平均年龄62 ± 2岁; 52%男性，90%白人）被随机分配至三种剂量的维生素C组。总体依从性为48 +/-2%。在维生素C补充阶段，平均收缩压（SBP）和舒张压（DBP）均下降[平均SBP下降4.5 ± 1.8 mm Hg（P
The effect of vitamin C on blood pressure is not well established. This is a randomized, double-blind control trial. Eligible patients were followed for 8 months. Patients were randomized to 500, 1000, or 2000 mg vitamin C. During each visit, a history including medication change was obtained and standardized blood pressure measurements were performed. A 1-week dietary diary was filled out before each visit. Multiple regression analysis and subsequent multiple comparisons were used for data analysis. Fifty-four patients satisfied our criteria and agreed to participate. Thirty-one patients (mean age, 62 +/- 2 years; 52% men, 90% whites) were randomized to the three doses of vitamin C. Overall compliance was 48 +/- 2%. Both mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased during the vitamin C supplementation phase [mean SBP dropped by 4.5 +/- 1.8 mm Hg (P