Association of a Human FABP1 Gene Promoter Region Polymorphism with Altered Serum Triglyceride Levels.
Association of a Human FABP1 Gene Promoter Region Polymorphism with Altered Serum Triglyceride Levels.
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人类 FABP1 基因启动子区域多态性与血清甘油三酯水平改变的关联。
DOI：
10.1371/journal.pone.0139417
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Lin X
中科院分区：
文献类型：
--
作者：
Peng XE;Wu YL;Zhu YB;Huang RD;Lu QQ;Lin X
肝脏脂肪酸结合蛋白L又称脂肪酸结合蛋白1，是肝脂代谢的关键调节因子。FABP1水平升高与心血管疾病(CVD)和代谢综合征的风险增加相关。在这项研究中，我们研究了FABP1基因启动子变异与中国人群血清FABP1和血脂水平的关系。对福州市中国地区1182名健康志愿者进行了FABP1基因启动子单核苷酸多态(SNPs)基因分型。结果显示，只有rs2919872G>；A变异与血清甘油三酯浓度显著相关(P=0.032)，与rs2919872G等位基因相比，rs2919872A等位基因显著降低血清甘油三酯浓度，该等位基因显著降低FABP1启动子活性(P<；0.05)。Rs2919872A等位基因携带者血清FABP1水平显著低于G等位基因携带者(P<0.01)。多元线性回归分析显示，rs2919872A等位基因与血清FABP_1水平呈负相关(β=-0.320，P=0.003)，而血清TG水平与血清FABP_1水平呈正相关(β=0.487，P=0.014)。我们的数据提示，与rs2919872G等位基因相比，rs2919872A等位基因降低了FABP1启动子的转录活性，从而可能将FABP1基因的变异与甘油三酯水平联系起来。
Liver fatty acid-binding protein (L-FABP), also known as fatty acid-binding protein 1 (FABP1), is a key regulator of hepatic lipid metabolism. Elevated FABP1 levels are associated with an increased risk of cardiovascular disease (CVD) and metabolic syndromes. In this study, we examine the association of FABP1 gene promoter variants with serum FABP1 and lipid levels in a Chinese population. Four promoter single-nucleotide polymorphisms (SNPs) of FABP1 gene were genotyped in a cross-sectional survey of healthy volunteers (n = 1,182) from Fuzhou city of China. Results showed that only the rs2919872 G>A variant was significantly associated with serum TG concentration(P = 0.032).Compared with the rs2919872 G allele, rs2919872 A allele contributed significantly to reduced serum TG concentration, and this allele dramatically decreased the FABP1 promoter activity(P < 0.05). The rs2919872 A allele carriers had considerably lower serum FABP1 levels than G allele carriers (P < 0.01). In the multivariable linear regression analysis, the rs2919872 A allele was negatively associated with serum FABP1 levels (β = —0.320, P = 0.003), while serum TG levels were positively associated with serum FABP1 levels (β = 0.487, P = 0.014). Our data suggest that compared with the rs2919872 G allele, the rs2919872 A allele reduces the transcriptional activity of FABP1 promoter, and thereby may link FABP1 gene variation to TG level in humans.