Androgen inhibition of sexual receptivity is modulated by estrogen.
Androgen inhibition of sexual receptivity is modulated by estrogen.
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雄激素对性接受的抑制是由雌激素调节的。
DOI：
10.1016/j.physbeh.2010.11.033
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发表时间：
2011
影响因子：
2.9
通讯作者：
Clark,AnnS
中科院分区：
文献类型：
--
作者：
Kirkpatrick,MegE;Clark,AnnS
长期给药苯甲酸雌二醇（estradiol benzoate， EB）诱导的去卵巢大鼠的性接受性可以通过同时给药雄激素来抑制。实验1考察了雄激素作用时间和剂量对雌激素诱导的性接受能力的抑制作用。去卵巢大鼠给予EB（每只大鼠每天2.0μg）治疗6d，并进行性接受性试验（试验第1天）。EB治疗持续15天，同时每日给予三种剂量丙酸二氢睾酮（DHTP; 7.5、0.75、0.075mg/kg）或3α-雄甾二醇（3α-二醇；3.75、1.0、0.375mg/kg）中的一种。在雄激素/载体治疗期的第3、6、14和15天（试验第II-V天）进行四次性接受性测试。第15天（试验第V天），大鼠在试验前4h注射黄体酮（1.0mg /只）。实验2采用相同的实验设计，考察了增加雌激素剂量对雄激素抑制性接受性的影响。切除卵巢的大鼠分别给予2种剂量的EB(2.0或10.0μg / d)，同时每日给予DHTP （7.5mg/kg）或3α-二醇（3.75mg/kg）。实验1中，最高剂量的DHTP和3α-二醇均能显著抑制雌激素诱导的性接受性。实验2的数据表明，增加EB剂量可以减缓DHTP的抑制作用，但不能减缓3α-二醇的抑制作用。
Sexual receptivity induced in ovariectomized rats by the long-term administration of estradiol benzoate (EB) can be inhibited by concurrent administration of androgens. Experiment 1 examined the role of time course and dose of androgens in the inhibition of estrogen-induced sexual receptivity. Ovariectomized rats were treated with EB (2.0μg per rat per day) for 6days and tested for sexual receptivity (Test Day I). EB treatment continued for 15days concomitant with daily administration of one of three doses of dihydrotestosterone propionate (DHTP; 7.5, 0.75, 0.075mg/kg) or 3α-androstanediol (3α-Adiol; 3.75, 1.0, 0.375mg/kg). Four tests for sexual receptivity were conducted on days 3, 6, 14, and 15 of the androgen/vehicle treatment period (Test Days II–V). On Day 15 (Test Day V), the rats received progesterone (1.0mg per rat) 4h before testing. Using the same experimental design, Experiment 2 examined the effect of increasing the dose of estrogen on the androgenic inhibition of sexual receptivity. Ovariectomized rats were treated with one of two doses of EB (2.0 or 10.0μg per rat per day) concomitant with daily administration of DHTP (7.5mg/kg) or 3α-Adiol (3.75mg/kg). In Experiment 1, the highest doses of both DHTP and 3α-Adiol significantly inhibited estrogen-induced sexual receptivity. Data from Experiment 2 indicate that the inhibitory effects of DHTP but not 3α-Adiol can be moderated by an increased dose of EB.