Chronic toxicity and oncogenicity bioassay of inhaled ethyl acrylate in Fischer 344 rats and B6C3F1 mice.
Chronic toxicity and oncogenicity bioassay of inhaled ethyl acrylate in Fischer 344 rats and B6C3F1 mice.
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Fischer 344 大鼠和 B6C3F1 小鼠吸入丙烯酸乙酯的慢性毒性和致癌性生物测定。
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发表时间：
1985
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通讯作者：
J. A. Ayres
中科院分区：
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作者：
R. Miller;J. T. Young;R. Kociba;D. Keyes;K. Bodner;L. Calhoun;J. A. Ayres
雄性和雌性Fischer 344大鼠和B6C3F1小鼠分别暴露于0、25或75 ppm（0、0.10或0.31 mg/l）的丙烯酸乙酯蒸气中，每天6小时，每周5天，总共27个月。另外的大鼠和小鼠暴露于225ppm （0.92 mg/l）中6个月，然后再暴露21个月。在这三个暴露组的动物中，鼻黏膜的嗅觉部分都出现了组织病理学变化。这些显微镜下暴露相关的变化是浓度依赖性的，主要是在鼻腔内病变的分布方面。一般来说，正常由嗅觉上皮排列的鼻黏膜区域发生改变，而由呼吸上皮排列的区域相对未受影响。没有迹象表明在大鼠或小鼠的任何器官或组织中有致癌反应。在一项后续研究中，Fischer 344大鼠和B6C3F1小鼠暴露于5 ppm (0.02 mg/l) 24个月后，鼻黏膜没有出现与治疗相关的变化。
Male and female Fischer 344 rats and B6C3F1 mice were exposed to 0, 25 or 75 ppm (0, 0.10 or 0.31 mg/l) ethyl acrylate vapors, 6 hours per day, 5 days per week, for a total of 27 months. Additional rats and mice were exposed to 225 ppm (0.92 mg/l) for 6 months and then held for 21 additional months post-exposure. Histopathologic changes in olfactory portions of the nasal mucosa were present in animals in all of these three exposure groups. These microscopic exposure-related changes were concentration-dependent, primarily in terms of distribution of the lesions within the nasal cavity. Generally those areas of the nasal mucosa normally lined by olfactory epithelium were altered, while the regions lined by respiratory epithelium were relatively unaffected. There was no indication of an oncogenic response in any organ or tissue in either rats or mice. A follow-up study in which Fischer 344 rats and B6C3F1 mice were exposed to 5 ppm (0.02 mg/l) for 24-months revealed no treatment-related changes in the nasal mucosa.