New mechanism of chromatin compartmentalization by BRD2.
New mechanism of chromatin compartmentalization by BRD2.
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BRD2 染色质区室化的新机制。
DOI：
10.1016/j.tig.2022.06.016
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Wang,Siyuan
中科院分区：
文献类型：
--
作者：
Cheng,Yubao;Wang,Siyuan
3D基因组区室化的分子机制仍然是一个谜。Xie等发现，布罗莫结构域和末端外（BET）家族支架蛋白BRD2促进了粘着蛋白丢失后可接近的染色质结构域的区室化.环挤压和区室化之间的拮抗性相互作用调节染色质折叠。
The molecular mechanism underlying 3D genome compartmentalization remains a mystery. Xie et al.found that the bromodomain and extraterminal (BET) family scaffold protein BRD2 promotes the compartmentalization of the accessible chromatin domains after cohesin loss. An antagonistic interplay between loop extrusion and compartmentalization modulates chromatin folding.