Preferential solvation stabilization for hydrophobic polymeric nanoparticle fabrication
Preferential solvation stabilization for hydrophobic polymeric nanoparticle fabrication
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DOI：
10.1021/jp0446480
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发表时间：
2005-07-28
影响因子：
3.3
通讯作者：
Chung, TS
中科院分区：
文献类型：
--
作者：
Xiong, JY;Liu, XY;Chung, TS
聚合物分子的优先溶剂化和溶剂与非溶剂分子之间的强EPD-EPA（EPD，电子对供体; EPA，电子对受体）相互作用被发现在两种芳香族聚酰亚胺（AP）纳米粒子的制备中具有重要意义。使用液-液相分离方法制备不含表面活性剂但稳定的AP纳米颗粒。AP纳米颗粒的稳定性可以通过由非溶剂->溶剂-> AP（a -> B表示组分B被组分a溶剂化）形式的溶剂化稳定链产生的溶剂化多层来实现。通过使用不同类型的分子探针的许多比较实验来鉴定这种稳定链的意义。另一方面，发现AP纳米颗粒的形成受成核过程控制，因此颗粒尺寸由成核速率控制。在超声波引起的强烈局部运动下，可以达到非常高的过饱和水平，从而导致非常高的成核速率。这种效应被发现是非常有用的亚50纳米AP纳米粒子的制造。
Preferential solvation of polymer molecules and strong EPD-EPA (EPD, electron pair donor; EPA, electron pair acceptor) interaction between solvent and nonsolvent molecules were found to be of great significance in the fabrication of two kinds of aromatic polyimide (AP) nanoparticles. Surfactant free yet stable AP nanoparticles were prepared using a liquid-liquid phase separation method. The stability of the AP nanoparticles can be achieved by the solvation multilayer resulting from a solvation stabilization chain in the form of nonsolvent -> solvent -> AP (a -> b denotes that component b is solvated by component a). The significance of this stabilization chain was identified by many comparative experiments using different types of molecular probes. On the other hand, the formation of AP nanoparticles was found to be governed by a nucleation process and therefore the particle size is controlled by the nucleation rate. A very high level of supersaturation can be attained under the intensive local motions induced by ultrasound, resulting in a very high nucleation rate. This effect was found to be extremely useful in the fabrication of sub-50 nm AP nanoparticles.