The association between scalp hair-whorl direction, handedness and hemispheric language dominance: Is there a common genetic basis of lateralization?
The association between scalp hair-whorl direction, handedness and hemispheric language dominance: Is there a common genetic basis of lateralization?
复制标题
DOI：
10.1016/j.neuroimage.2006.12.025
复制
发表时间：
2007-04-01
期刊：
影响因子：
5.7
通讯作者：
Knecht, Stefan
中科院分区：
文献类型：
--
作者：
Jansen, Andreas;Lohmann, Hubertus;Knecht, Stefan
人类大脑的两个半球在功能上是不对称的。左脑倾向于支配语言，在控制手部灵巧性方面占优势。这些不对称性背后的机制尚不清楚。对遗传和环境因素进行了讨论。最近，非典型的逆时针方向的毛发旋向与非右利手和非典型半球语言优势的可能性增加有关。这些发现是有趣和重要的，因为毛旋方向是偏侧化的结构标志，并可以为大脑功能侧化提供一个容易观察的解剖学线索。基于关于惯用手和毛旋方向的数据，Amar War提出了一个遗传模型(随机-隐性模型)，即带有两个等位基因的单基因控制惯用手和毛旋方向(Klar，A.J.S.，2003)。人类的惯用手和头皮的发旋方向是从共同的遗传机制发展而来的。遗传学165,269-276)。本研究旨在进一步探讨头皮发旋方向与利手和大脑半球语言优势的关系。对1212名受试者进行了头皮发旋方向和惯用手的调查。此外，我们使用功能性经颅多普勒超声(FTCD)确定了212名受试者的大脑半球语言优势(通过词汇生成任务进行评估)。至于单一属性--发旋方向、利手和语言优势--我们复制了以前发表的结果。然而，我们没有发现发旋方向与语言优势或惯用手之间的联系。这些结果强烈反对惯用左撇子或语言偏侧化与头皮毛发螺旋方向的共同遗传基础。对发式的检查无助于我们确定语言优势。(C)2006 Elsevier Inc.保留所有权利。
The hemispheres of the human brain are functionally asymmetric. The left hemisphere tends to be dominant for language and superior in the control of manual dexterity. The mechanisms underlying these asymmetries are not known. Genetic as well as environmental factors are discussed.Recently, atypical anticlockwise hair-whorl direction has been related to an increased probability for non-right-handedness and atypical hemispheric language dominance. These findings are fascinating and important since hair-whorl direction is a structural marker of lateralization and could provide a readily observable anatomical clue to functional brain lateralization.Based on data on handedness and hair-whorl direction, Amar War proposed a genetic model ("random-recessive model") in that a single gene with two alleles controls both handedness and hair-whorl orientation (Klar, A.J.S., 2003. Human handedness and scalp hair-whorl direction develop from a common genetic mechanism. Genetics 165, 269-276). The present study was designed to further investigate the relationship between scalp hair-whorl direction with handedness and hemispheric language dominance. 1212 subjects were investigated for scalp hair-whorl direction and handedness. Additionally, we determined hemispheric language dominance (as assessed by a word generation task) in a subgroup of 212 subjects using functional transcranial Doppler sonography (fTCD). As for the single attributes hair-whorl direction, handedness, and language dominance - we reproduced previously published results. However, we found no association between hair-whorl direction and either language dominance or handedness. These results strongly argue against a common genetic basis of handedness or language lateralization with scalp hair-whorl direction. Inspection of hair patterns will not help us to determine language dominance. (c) 2006 Elsevier Inc. All rights reserved.