Effects of hypoxia on alveolar fluid transport capacity in rat lungs.
Effects of hypoxia on alveolar fluid transport capacity in rat lungs.
复制标题
DOI：
10.1152/jappl.2001.91.4.1766
复制
发表时间：
2001-10
影响因子：
3.3
通讯作者：
T. Sakuma;M. Hida;Yoshihiro Nambu;K. Osanai;H. Toga;Keiji Takahashi;N. Ohya;M. Inoue;Yoh Watanabe
中科院分区：
文献类型：
--
作者：
T. Sakuma;M. Hida;Yoshihiro Nambu;K. Osanai;H. Toga;Keiji Takahashi;N. Ohya;M. Inoue;Yoh Watanabe
关于缺氧对肺泡液体清除能力的影响的信息很少。我们测量了暴露于10%氧气长达120小时的大鼠的肺泡液体清除率、肺水量、血浆儿茶酚胺浓度和血清渗透压，并探索了肺泡液体清除率增加的机制。结果表明：低氧暴露48 h肺泡液体清除率无明显变化，72 ~ 120 h肺泡液体清除率升高，低氧时营养不良使基础肺泡液体清除率降低，而内源性去甲肾上腺素使肺泡液体净清除率升高，肺水容量和血清渗透压的变化与肺泡液体清除率的变化无关，低氧暴露后肺泡液体净清除率升高。4）施用β-肾上腺素能激动剂进一步增加肺泡液体清除率;和5）缺氧后复氧24小时内肺泡液体清除率恢复正常。总之，肺泡上皮细胞的液体运输能力增加，在大鼠暴露于缺氧。这可能是内源性去甲肾上腺素和营养障碍的组合调节缺氧条件下肺泡液体清除。
There is little information regarding the effect of hypoxia on alveolar fluid clearance capacity. We measured alveolar fluid clearance, lung water volume, plasma catecholamine concentrations, and serum osmolality in rats exposed to 10% oxygen for up to 120 h and explored the mechanisms responsible for the increase in alveolar fluid clearance. The principal results were 1) alveolar fluid clearance did not change for 48 h and then increased between 72 and 120 h of exposure to hypoxia; 2) although nutritional impairment during hypoxia decreased basal alveolar fluid clearance, endogenous norepinephrine increased net alveolar fluid clearance; 3) the changes of lung water volume and serum osmolality were not associated with those of alveolar fluid clearance; 4) an administration of beta-adrenergic agonists further increased alveolar fluid clearance; and 5) alveolar fluid clearance returned to normal within 24 h of reoxygenation after hypoxia. In conclusion, alveolar epithelial fluid transport capacity increases in rats exposed to hypoxia. It is likely that a combination of endogenous norepinephrine and nutritional impairment regulates alveolar fluid clearance under hypoxic conditions.