Role of intracellular calcium stores in hair-cell ribbon synapse.

Role of intracellular calcium stores in hair-cell ribbon synapse.
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DOI:
10.3389/fncel.2014.00162
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发表时间:
2014
影响因子:
5.3
通讯作者:
Ricci AJ
Ricci AJ
中科院分区:
医学2区
文献类型:
--
作者:
Castellano-Muñoz M;Ricci AJ

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细胞内钙库控制许多神经元功能,如兴奋性、基因表达、突触可塑性和突触释放。尽管在常规突触和带状突触中已经证实存在钙储存沿着钙诱导的钙释放(CICR),但其功能意义和细胞机制尚不清楚。本文综述了近年来CICR对中枢神经系统、视网膜和内耳的突触传递和突触可塑性的研究进展。此外,CICR在招募囊泡的毛细胞带状突触可释放池的潜在作用将具体讨论。
Intracellular calcium stores control many neuronal functions such as excitability, gene expression, synaptic plasticity, and synaptic release. Although the existence of calcium stores along with calcium-induced calcium release (CICR) has been demonstrated in conventional and ribbon synapses, functional significance and the cellular mechanisms underlying this role remains unclear. This review summarizes recent experimental evidence identifying contribution of CICR to synaptic transmission and synaptic plasticity in the CNS, retina and inner ear. In addition, the potential role of CICR in the recruitment of vesicles to releasable pools in hair-cell ribbon synapses will be specifically discussed.
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