Food Safety Concerns: Crop Breeding as a Potential Strategy to Address Issues Associated with the Recently Lowered Reference Doses for Perfluorooctanoic Acid and Perfluorooctane sulfonate.
Food Safety Concerns: Crop Breeding as a Potential Strategy to Address Issues Associated with the Recently Lowered Reference Doses for Perfluorooctanoic Acid and Perfluorooctane sulfonate.
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DOI：
10.1021/acs.jafc.9b04625
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发表时间：
2019-12
影响因子：
6.1
通讯作者：
L. Xiang;Yan-Wen Li;Peng-fei Yu;Nai-Xian Feng;Hai-Ming Zhao;Hui Li;Q. Cai;C. Mo;Qing X. Li
中科院分区：
文献类型：
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作者：
L. Xiang;Yan-Wen Li;Peng-fei Yu;Nai-Xian Feng;Hai-Ming Zhao;Hui Li;Q. Cai;C. Mo;Qing X. Li
全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）是广泛应用于工业和家庭产品中的全氟烷基物质。欧洲食品安全局和美国EPA最近将PFOA和PFOS的参考剂量(RfD)降低了4~1800倍。最近降低的 RfD 要求重新评估 PFOA 和 PFOS 通过食品消费产生的潜在人类健康风险。由于某些 PFOA 和 PFOS 的摄入量超过了 RfD，因此引起了严重的担忧。低积累作物品种的创新种植成为减少人类接触的一种选择。我们针对有毒金属和其他有机污染物，对 PFOA 和 PFOS 低积累作物品种进行了最新综述，包括品种鉴定、生理生化机制、分子吸收机制和分子对接。旨在呼吁人们关注并开展研究工作，以减少人类通过农作物消费摄入 PFOA 和 PFOS。
Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are perfluorinated alkyl substances widely used in industrial and domestic products. The European Food Safety Authority and U.S. EPA have recently lowered the reference doses (RfDs) for PFOA and PFOS 4~1800-fold. The recently lowered RfDs call for re-evaluation of potential human health risks from PFOA and PFOS via food consumption. Serious concerns arise because some intakes of PFOA and PFOS exceeded the RfDs. Innovative cultivation of low-accumulating crop varieties becomes an option to decrease human exposure. We present an up-to-date review on low-accumulating crop varieties for PFOA and PFOS, in reference to toxic metals and other organic pollutants, including the variety identification, physiological-biochemical mechanisms, and molecular uptake mechanisms and molecular docking. It is to call for attention and research efforts to decrease human intakes of PFOA and PFOS via crop consumption.