Elevated cyclin D1 expression is governed by plasma IGF-1 through Ras/Raf/MEK/ERK pathway in rumen epithelium of goats supplying a high metabolizable energy diet
Elevated cyclin D1 expression is governed by plasma IGF-1 through Ras/Raf/MEK/ERK pathway in rumen epithelium of goats supplying a high metabolizable energy diet
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DOI：
10.1111/jpn.12026
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发表时间：
2013-12-01
影响因子：
2.7
通讯作者：
Shen, Z.
中科院分区：
文献类型：
--
作者：
Lu, J.;Zhao, H.;Shen, Z.
本研究旨在探讨高代谢能日粮中胰岛素样生长因子1（IGF-1）诱导山羊瘤胃上皮细胞增殖的机制。本试验采用低代谢能（LL，n=9，ME：0.57MJ/kg（0.75）/d）和高代谢能（HL，n=9，ME：1.00MJ/（kg（0.75）/d））两种日粮，连续饲喂42天。HL组细胞周期蛋白D1 mRNA表达增强，使G（1）期时间缩短（p
The objective of this study was to explore the underlying mechanism of insulin-like growth factor 1 (IGF-1)-caused cell proliferation of rumen epithelium in goats fed a high metabolizable energy (ME) diet. In this study, young goats were fed either a low ME [LL, n=9, ME: 0.57MJ/kg(0.75)/day] or high ME [HL, n=9, ME: 1.00MJ/(kg(0.75)/day)] diet for 42day. The time duration of G(1)-phase was shortened as a result of enhanced expression of cyclin D1 mRNA in the HL group (p