CELLULAR AND MOLECULAR MECHANISMS OF DRUG-DEPENDENCE
CELLULAR AND MOLECULAR MECHANISMS OF DRUG-DEPENDENCE
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DOI：
10.1126/science.2903550
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发表时间：
1988-11-04
期刊：
影响因子：
56.9
通讯作者：
BLOOM, FE
中科院分区：
文献类型：
--
作者：
KOOB, GF;BLOOM, FE
在药物依赖行为研究的背景下，综述了三类滥用药物——阿片类药物、精神兴奋剂和乙醇的分子和细胞作用。将药物的即时效果与长期接触后观察到的效果进行比较。从这些药物的细胞和行为效应之间的联系提出了药物依赖的神经生物学基础。
The molecular and cellular actions of three classes of abused drugs—opiates, psychostimulants, and ethanol—are reviewed in the context of behavioral studies of drug dependence. The immediate effects of drugs are compared to those observed after long-term exposure. A neurobiological basis for drug dependence is proposed from the linkage between the cellular and behavioral effects of these drugs.