Mother-to-Child Transmission of Hepatitis B Virus in Ethiopia.
Mother-to-Child Transmission of Hepatitis B Virus in Ethiopia.
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DOI：
10.3390/vaccines9050430
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发表时间：
2021-04-26
期刊：
影响因子：
7.8
通讯作者：
Berhe N
中科院分区：
文献类型：
--
作者：
Johannessen A;Mekasha B;Desalegn H;Aberra H;Stene-Johansen K;Berhe N
高病毒载量和乙型肝炎e抗原（HBeAg）阳性结果是乙型肝炎病毒（HBV）母婴传播（MTCT）的危险因素。在撒哈拉以南非洲，人们对这些风险因素的分布以及儿童早期HBV传播知之甚少。在这项研究中，对年龄在18-45岁的埃塞俄比亚慢性乙型肝炎妇女进行了HBeAg和高病毒载量的评估。他们4岁以下的孩子被邀请进行病毒标志物评估，将活动性HBV感染定义为乙型肝炎s抗原（HBsAg）阳性和/或可检测的HBV DNA。总共428名感染hbv的妇女中有61名（14.3%）HBeAg阳性和/或病毒载量高。值得注意的是，病毒载量高于200,000 IU/mL的49名女性中有26名（53.1%）为HBeAg阴性。在感染HBV的母亲（中位年龄20个月）所生的89名儿童中，有9名（10.1%）有活动性HBV感染的证据。总之，七分之一的慢性乙型肝炎妇女有MTCT的危险因素，而HBeAg是高病毒载量的一个很差的预测因子。感染乙肝病毒的妇女所生的儿童中，有十分之一在6、10和14周龄时完成了乙肝疫苗接种，但仍获得了乙肝病毒感染。
High viral load and positive hepatitis B e-antigen (HBeAg) results are risk factors for mother-to-child transmission (MTCT) of hepatitis B virus (HBV). In sub-Saharan Africa, little is known about the distribution of these risk factors, as well as early childhood HBV transmission. In this study, Ethiopian women aged 18–45 years with chronic hepatitis B were assessed for the presence of HBeAg and high viral load. Their children below 4 years of age were invited for assessment of viral markers, defining active HBV infection as a positive hepatitis B s-antigen (HBsAg) and/or detectable HBV DNA. In total, 61 of 428 HBV-infected women (14.3%) had a positive HBeAg result and/or a high viral load. Of note, 26 of 49 women (53.1%) with viral load above 200,000 IU/mL were HBeAg negative. Among 89 children born of HBV-infected mothers (median age 20 months), 9 (10.1%) had evidence of active HBV infection. In conclusion, one in seven women with chronic hepatitis B had risk factors for MTCT, and HBeAg was a poor predictor of high viral load. One in ten children born of HBV-infected women acquired HBV-infection despite completing their scheduled HBV vaccination at 6, 10 and 14 weeks of age.
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DOI：
10.1016/s2468-1253(20)30307-1
发表时间：
2021-03
期刊：
The lancet. Gastroenterology & hepatology
影响因子：
--
作者：
Tan M;Bhadoria AS;Cui F;Tan A;Van Holten J;Easterbrook P;Ford N;Han Q;Lu Y;Bulterys M;Hutin Y
通讯作者：
Hutin Y
影响因子：
5.5
作者：
Andersson, M. I.;Maponga, T. G.;Tedder, R. S.
通讯作者：
Tedder, R. S.
影响因子：
25.7
作者：
Aberra, Hanna;Desalegn, Hailemichael;Johannessen, Asgeir
通讯作者：
Johannessen, Asgeir
影响因子：
3.3
作者：
Seck, Abdoulaye;Ndiaye, Fatou;Shimakawa, Yusuke
通讯作者：
Shimakawa, Yusuke
影响因子：
35.7
作者：
Indolfi, Giuseppe;Easterbrook, Philippa;Penazzato, Martina
通讯作者：
Penazzato, Martina