Differential expression of microRNAs in different disease states.
Differential expression of microRNAs in different disease states.
复制标题
DOI：
10.1161/circresaha.111.247437
复制
发表时间：
2012-02-17
影响因子：
20.1
通讯作者：
Abdellatif M
中科院分区：
文献类型：
--
作者：
Abdellatif M
由于转录或转录后调节的干扰而导致的基因表达的干扰是导致不同疾病状态的细胞功能障碍的主要原因之一。大约十年前，在哺乳动物细胞中发现的microRNAs（miRNAs）使我们重新关注发病过程中的转录后调控机制。这些微小的转录后调节因子在迄今为止研究的几乎每种疾病中都有差异表达，并且可以通过特异性结合其信使RNA来调节基因的表达。由于它们能够同时靶向多个功能相关的基因，它们被证明是潜在的强大治疗剂/靶标。在这篇综述中，我们将重点介绍在更常见的心血管疾病中差异调节的miRNAs，它们的靶点和潜在功能。
Disturbances in gene expression as a result of perturbed transcription or posttranscriptional regulation is one of the main causes of cellular dysfunction that underlies different disease states. About a decade ago, the discovery of microRNAs (miRNAs) in mammalian cells has renewed our focus on posttranscriptional regulatory mechanisms during pathogenesis. These tiny posttranscriptional regulators are differentially expressed in almost every disease that has been studied-to-date and can modulate a gene’s expression via specifically binding to its messenger RNA. Due to their capacity to simultaneously target multiple, functionally-related, genes, they are proving to be potentially powerful therapeutic agents/targets. In this review we will focus on the miRNAs that are differentially regulated in the more common cardiovascular pathologies, their targets, and potential function.