Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages
Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages
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DOI：
10.1142/s0192415x15500457
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发表时间：
2015-01-01
影响因子：
5.7
通讯作者：
Hong, Seung-Heon
中科院分区：
文献类型：
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作者：
Kim, Dae-Seung;Lee, Hyun-Ja;Hong, Seung-Heon
在这项研究中，我们发现α-蒎烯通过抑制小鼠腹腔巨噬细胞中的丝裂原活化蛋白激酶（MAPK）和核因子-κ B（NF-κ B）通路而表现出抗炎活性。在许多针叶树和迷迭香的油中发现α-蒎烯。我们使用小鼠腹腔巨噬细胞研究了α-蒎烯对脂多糖（LPS）诱导的炎症反应的抑制作用。α-Pinene可显着降低脂多糖诱导的白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-alpha）和一氧化氮（NO）的产生。α-Pinene还可抑制脂多糖刺激的巨噬细胞中诱导型一氧化氮合酶（iNOS）和环氧合酶-2（考克斯-2）的表达。此外，MAPK和NF-κ B B的活化通过α-蒎烯处理而减弱。这些结果表明，α-蒎烯具有抗炎作用，它是一种潜在的候选药物，用于治疗各种炎症性疾病。
In this study, we found that alpha-pinene (alpha -pinene) exhibits anti-inflammatory activity through the suppression of mitogen-activated protein kinases (MAPKs) and the nuclear factor-kappa B (NF-kappa B) pathway in mouse peritoneal macrophages. alpha-Pinene is found in the oils of many coniferous trees and rosemary. We investigated the inhibitory effects of alpha-Pinene on inflammatory responses induced by lipopolysaccharide (LPS) using mouse peritoneal macrophages. alpha-Pinene significantly decreased the LPS-induced production of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO).alpha-Pinene also inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions in LPS-stimulated macrophages. Additionally, the activations of MAPKs and NF-kappa B were attenuated by means of alpha-pinene treatment. These results indicate that alpha-pinene has an anti-inflammatory effect and that it is a potential candidate as a new drug to treat various inflammatory diseases.