Electrospun Composite Nanofiber Fabrics Containing Uniformly Dispersed Antimicrobial Agents As an Innovative Type of Polymeric Materials with Superior Antimicrobial Efficacy
Electrospun Composite Nanofiber Fabrics Containing Uniformly Dispersed Antimicrobial Agents As an Innovative Type of Polymeric Materials with Superior Antimicrobial Efficacy
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DOI：
10.1021/am100018k
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发表时间：
2010-04-01
影响因子：
9.5
通讯作者：
Sun, Yuyu
中科院分区：
文献类型：
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作者：
Sun, Xinbo;Zhang, Lifeng;Sun, Yuyu
在这里，我们报道了含有均匀分散的抗菌剂的电纺复合纳米纤维织物，具有大的表观质量比，是一种新型的抗菌聚合物材料，具有耐用、不可浸出和生物相容的特性，更重要的是，具有优异的抗菌效果。具体地说，制备并评价了含有N-卤胺抗菌剂bis(N-chloro-2，2，6，6-tetramethyl-4-piperidinyl)-BTMP(CI-BTMP)的电纺醋酸酯(CA)纳米纤维织物：抗菌效果结果表明，电纺复合纳米纤维织物的抗菌性能显著优于含有相同数量的CA和CI-BTMP的溶液浇铸薄膜的对照样品。此外，台盼蓝测试结果表明，电纺复合纳米纤维织物也具有良好的哺乳动物细胞活力。开发的电纺复合纳米纤维织物具有优异的抗菌效果，有望在生物医学、卫生等许多领域得到重要应用。
Herein we report that electrospun composite nanofiber fabrics containing uniformly dispersed antimicrobial agents and having large surface-to-mass ratios are an innovative type of antimicrobial polymeric materials with durable, nonleachable, and biocompatible characteristics, and more importantly, superior antimicrobial efficacy. Specifically, electrospun cellulose acetate (CA) nanofiber fabrics containing an N-halamine antimicrobial agent of bis(N-chloro-2,2,6,6-tetramethyl-4-piperidinyl) sebacate (CI-BTMP) were prepared and evaluated: the results of antimicrobial efficacy indicated that the electrospun composite nanofiber fabrics substantially outperformed the control samples that were solution-cast films containing identical amounts of CA and CI-BTMP. Additionally, the results of trypan blue assay test suggested that the electrospun composite nanofiber fabrics also had excellent mammal cell viability. The developed electrospun composite nanofiber fabrics with superior antimicrobial efficacy are expected to find vital applications in biomedical, hygienic, and many other fields.