Comorbid Sleep Disturbances in Neurologic Disorders.
Comorbid Sleep Disturbances in Neurologic Disorders.
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DOI：
10.1212/con.0000000000000501
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发表时间：
2017-08-01
期刊：
影响因子：
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通讯作者：
Vaughn, Bradley V
中科院分区：
文献类型：
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作者：
Ju, Yo-El S;Videnovic, Aleksandar;Vaughn, Bradley V
综述目的：本文综述了睡眠障碍与常见神经功能障碍的关系。研究结果：多种神经功能障碍常合并睡眠障碍。在许多情况下，睡眠功能和神经疾病之间似乎存在双向关系，因此，治疗并发的睡眠障碍可能会改善神经疾病的症状。总结：神经疾病通常与睡眠异常有关。睡眠会影响癫痫和头痛的严重程度，治疗睡眠障碍可能会改善癫痫发作和头痛的频率。阿尔茨海默病的特点是昼夜节律延迟和夜间睡眠不佳，与阻塞性睡眠呼吸暂停密切相关。帕金森病与几种睡眠障碍有关，包括失眠、不宁腿综合症、快速眼动(REM)睡眠行为障碍、日间过度睡眠和睡眠呼吸障碍。在肌萎缩侧索硬化症和其他神经肌肉疾病中，低通气量通常最初表现为睡眠问题，而非侵入性机械通气治疗可以改善生存和生活质量。
PURPOSE OF REVIEW: This article provides a review of disturbances of sleep comorbid with common neurologic disorders.RECENT FINDINGS: A wide variety of neurologic disorders are frequently complicated by comorbid sleep disturbances. In many cases, a bidirectional relationship appears to occur between sleep function and the neurologic disease, such that treatment of comorbid sleep disturbances may improve the symptoms of the neurologic disease.SUMMARY: Neurologic disorders are often associated with abnormalities of sleep. Sleep influences the severity of both epilepsy and headache, and treatment of comorbid sleep disorders may improve seizure and headache frequency. Alzheimer disease is characterized by circadian phase delay and poor nighttime sleep and is strongly associated with obstructive sleep apnea. Parkinson disease is associated with several sleep disorders, including insomnia, restless legs syndrome, rapid eye movement (REM) sleep behavior disorder, daytime hypersomnia, and sleep-disordered breathing. Hypoventilation in amyotrophic lateral sclerosis and other neuromuscular disorders often presents initially with sleep problems, and treatment with noninvasive ventilation improves survival and quality of life.