Type II collagen autoimmunity in otosclerosis and Meniere's Disease.
Type II collagen autoimmunity in otosclerosis and Meniere's Disease.
复制标题
耳硬化症和梅尼埃病中的 II 型胶原自身免疫。
DOI：
10.1126/science.7112122
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发表时间：
1982
期刊：
影响因子：
56.9
通讯作者：
S. Dixit
中科院分区：
文献类型：
--
作者：
T. Yoo;J. Stuart;A. Kang;A. Townes;K. Tomoda;S. Dixit
对耳硬化症患者和梅尼埃病患者进行了I型、II型和IV型胶原抗体检测。这些患者的II型胶原抗体水平明显高于对照组，而I型和IV型胶原抗体水平无明显差异。这些观察结果提示II型胶原自身免疫在耳硬化症和梅尼埃病的发病机制中可能起作用。
Antibodies to collagen types I, II, and IV were measured in patients with otosclerosis and patients with Meniere's disease. Levels of antibodies to type II collagen were significantly higher in these patients than in control subjects, while no differences were found among levels of antibodies to collagen type I or type IV. These observations suggest a possible role for type II collagen autoimmunity in the etiology of otosclerosis and Meniere's disease.