Hijacking of the host-cell response and translational control during influenza virus infection
Hijacking of the host-cell response and translational control during influenza virus infection
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DOI：
10.1016/j.virusres.2005.10.013
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发表时间：
2006-07-01
期刊：
影响因子：
5
通讯作者：
Katze, Michael G.
中科院分区：
文献类型：
--
作者：
Kash, John C.;Goodman, Alan G.;Katze, Michael G.
流感病毒是一个主要的公共卫生问题，美国每年有3.6万人死于流感大流行，如1918年，导致全球死亡人数超过2000万人。最近，人们非常关注将高致病性H5N1禽流感病毒引入人群。流感病毒已经进化出复杂的翻译控制策略，利用帽依赖的翻译起始机制，涉及病毒和宿主细胞蛋白的招募，以优先合成病毒蛋白并阻止抗病毒反应的激活。流感病毒是正黏液病毒科负链分节RNA病毒的一员，由于病毒复制策略与包括宿主防御和应激途径在内的正常细胞过程密切相关，它代表了一个特别有吸引力的模型系统。在本章中，我们回顾了流感病毒感染细胞和应激细胞中翻译控制之间的相似之处，重点关注病毒mrna的选择性翻译以及dsRNA和宿主抗病毒反应的拮抗作用。此外，我们将讨论如何使用基因组技术，如DNA微阵列和高通量蛋白质组学，以获得病毒感染期间蛋白质合成控制的新见解，并提供病毒与宿主相互作用的近全面视图。(c) 2005 Elsevier B.V.版权所有
Influenza virus is a major public health problem with annual deaths in the US of 36,000 with pandemic outbreaks, such as in 1918, resulting in deaths exceeding 20 million worldwide. Recently, there is much concern over the introduction of highly pathogenic avian influenza H5N1 viruses into the human population. Influenza virus has evolved complex translational control strategies that utilize cap-dependent translation initiation mechanisms and involve the recruitment of both viral and host-cell proteins to preferentially synthesize viral proteins and prevent activation of antiviral responses. Influenza virus is a member of the Orthomyxoviridae family of negative-stranded, segmented RNA viruses and represents a particularly attractive model system as viral replication strategies are closely intertwined with normal cellular processes including the host defense and stress pathways. In this chapter, we review the parallels between translational control in influenza virus infected cells and in stressed cells with a focus on selective translation of viral mRNAs and the antagonism of the dsRNA and host antiviral responses. Moreover, we will discuss how the use of genomic technologies such as DNA microarrays and high through-put proteomics can be used to gain new insights into the control of protein synthesis during viral infection and provide a near comprehensive view of virus-host interactions. (c) 2005 Elsevier B.V. All rights reserved.