Immunohistochemical evaluation of human epidermal growth factor receptor 2 and estrogen and progesterone receptors in breast carcinoma in Jordan
Immunohistochemical evaluation of human epidermal growth factor receptor 2 and estrogen and progesterone receptors in breast carcinoma in Jordan
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DOI：
10.1186/bcr1200
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发表时间：
2005-01-01
影响因子：
7.4
通讯作者：
Al Hamad, M
中科院分区：
文献类型：
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作者：
Almasri, NM;Al Hamad, M
虽然乳腺癌（BC）是影响约旦女性的最常见恶性肿瘤，约旦的受影响人口比西方国家年轻，但没有关于其生物学特征的信息。本研究的目的是评估约旦BC中雌激素受体（ER）和孕激素受体（PR）的表达以及Her-2/neu过表达，并将这些表达与BC的其他预后参数（如组织学类型、组织学分级、肿瘤大小、患者年龄、方法本研究是在约旦科技大学病理学系进行的回顾性研究。对1995 ~ 1998年确诊的91例乳腺癌进行回顾性分析。我们用免疫组织化学方法来评估ER、PR和Her-2的表达。结果Her-2在24%的乳腺癌组织中呈高表达，与年龄、肿瘤大小、分级及腋窝淋巴结转移有关。Her-2阳性病例的平均年龄为42岁，而Her-2阴性病例的平均年龄为53岁（p = 0.0001）。Her-2表达与ER、PR表达呈负相关。Her-2阳性肿瘤倾向于大于Her-2阴性肿瘤，T3肿瘤中35%过表达，而T2肿瘤中22%过表达（p = 0.13）。Her-2阳性病例腋窝转移率较高，但未达到统计学显著性。结论约旦女性乳腺癌中Her-2过表达率为24%。Her-2过表达与发病年龄小、肿瘤体积大有关，与ER和PR表达呈负相关。五分之一的癌Her-2阳性，ER阴性。这一组似乎代表了一种侵袭性形式的BC，在年轻时表现为大的原发性肿瘤和高比率的四个或更多个腋窝淋巴结转移。
Introduction Although breast carcinoma ( BC) is the most common malignancy affecting Jordanian females and the affected population in Jordan is younger than that in the West, no information is available on its biological characteristics. Our aims in this study are to evaluate the expression of estrogen receptor ( ER) and progesterone receptor ( PR) and Her-2/neu overexpression in BC in Jordan, and to compare the expression of these with other prognostic parameters for BC such as histological type, histological grade, tumor size, patients' age, and number of lymph node metastases.Method This is a retrospective study conducted in the Department of Pathology at Jordan University of Science and Technology. A confirmed 91 cases of BC diagnosed in the period 1995 to 1998 were reviewed and graded. We used immunohistochemistry to evaluate the expression of ER, PR, and Her-2. Immunohistochemical findings were correlated with age, tumor size, grade and axillary lymph node status.Results Her-2 was overexpressed in 24% of the cases. The mean age of Her-2 positive cases was 42 years as opposed to 53 years among Her-2 negative cases ( p = 0.0001). Her-2 expression was inversely related to ER and PR expression. Her-2 positive tumors tended to be larger than Her-2 negative tumors with 35% overexpression among T3 tumors as opposed to 22% among T2 tumors ( p = 0.13). Her-2 positive cases tended to have higher rates of axillary metastases, but this did not reach statistical significance. ER and PR positive cases were seen in older patients with smaller tumor sizes.Conclusion Her-2 overexpression was seen in 24% of BC affecting Jordanian females. Her-2 overexpression was associated with young age at presentation, larger tumor size, and was inversely related to ER and PR expression. One-fifth of the carcinomas were Her-2 positive and ER negative. This group appears to represent an aggressive form of BC presenting at a young age with large primary tumors and a high rate of four or more axillary lymph node metastases.